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皮肤Merkel细胞癌的研究进展 被引量：2

Study progressions in Merkel cell carcinoma
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摘要 Merkel细胞癌(MCC)是一种好发于皮肤的少见恶性神经内分泌瘤,预后较差,易局部复发和转移。MCC的临床诊断可参考"AEIOU"五元音法,但必须由组织病理学确诊。MCC在高度紫外线暴露的地区较常见,且与免疫抑制密切相关。MCC可能与Merkel细胞多瘤病毒(MCPyV)相关。目前MCC尚无成熟的治疗方案,但首选手术治疗并常常辅助放疗或化疗。 Merkel cell carcinoma（MCC） is an unusual and potentially aggressive neuroendocrine carcinoma of skin with a high tendency for local recurrence and distant spread.＂AEIOU＂ standard is used as reference for clinical diagnosis,but the diagnosis must be confirmed by pathologic evidence.MCPyV,UV exposure and immunosuppressive appeared to play a role in the onset and development MCC.Surgery is primary modality for Merkel cell carcinoma,and adjuvant radiation therapy with systemic chemotherapy reduces local recurrence.
作者 张辉 王峰
机构地区 成都中医药大学临床医学院 四川大学华西医院肿瘤中心
出处 《临床肿瘤学杂志》 CAS 2011年第5期468-471,共4页 Chinese Clinical Oncology
关键词 MERKEL细胞癌 手术治疗 放射治疗 化学治疗 进展 Merkel cell carcinoma Operation Radiotherapy Chemotherapy Progression
分类号 R739.5 [医药卫生—肿瘤]
  • 相关文献

参考文献38

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二级参考文献3

  • 1Bickle K, Glass F, Messina J L, et al. Merkel cell carcinoma: A clinical histopathologic and immunohischemical review[J]. Semin Cutan Med Surg, 2004, 23(1):46-53.
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共引文献4

同被引文献16

  • 1曾自力.空气间隙对电子束吸收剂量的影响[J].中国辐射卫生,2006,15(4):465-465. 被引量：2
  • 2PhillipHM,EduardoC,ScottG.Dermat.pathology[M].北京:北京大学医学出版社,2007:1230-1238.
  • 3Merritt H, Sniegowski MC, Esmaeli B. Merkel cell carcinoma of the eyelid and periocular region[J]. Cancers (Basel) ,2014,6(2) : 1128-1137. doi : 10. 3390/cancers6021128.
  • 4Becker JC, Schrama D, Houben R. Merkel cell carcinoma[ J ]. Cell Mol Life Sci ,2009,66 ( 1 ) : 1-8. doi : 10. 1007/s00018-008-8483-6.
  • 5Paulson KG, Lemos BD, Feng B, et al. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L- Myc [ J ]. J Invest Dermatol,2009,129 ( 6 ) : 1547-1555. doi : 10. 1038/ jid. 2008. 365.
  • 6Garneski KM, DeCaprio JA, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma? [ J/OL]. Genomc Biol, 2008, 9 ( 6 ) : 228 [ 2015 -02 -23 ]. http ://www. genomebiology, tom/content/ pdf/gb-2008 -9-6-228. doi : 10. 1186/gb -2 008-9-6 -228.
  • 7Missotten GS, de Wolff-Rouendaal "D, de Keizer RJ. Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression [ J ]. Ophthalmology ,2008,115 ( 1 ) : 195-201.
  • 8Pulitzer MP,Amin BD, Busam KJ. Merkel cell carcinoma: review [ J ]Ady Anat Pathol, 2009, 16 ( 3 ) : 135 - 144. doi: 10. 1097/PAP. Ob013e3181 a12f5 a.
  • 9Bickle K, Glass LF, Messina JL, et al. Merkel cell carcinoma : a clinical, histopathologic, and immunohistoehemieal review [ J ]. Semin Cutan Med Surg,2004,23 ( 1 ) : 46-53.
  • 10Peters GB,Meyer DR, Shields JA, ct al. Management and prognosis of M erkel cell carcinoma of the eyelid [ J ]. Ophthalmology ,2001,108 (9) : 1575-1579.

引证文献2

二级引证文献9

临床肿瘤学杂志
2011年 第5期

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