非那雄胺与米诺地尔治疗男性雄激素性秃发疗效比较

Comparison of efficacy of finasteride and minoxidil in the treatment of male androgenetic alopecia

目的:比较1 mg非那雄胺、5%米诺地尔及两者联合治疗男性雄激素性秃发(AGA)的疗效。方法:观察206例Hamilton-Norwood分级为Ⅲv、Ⅳ和V级的男性AGA患者,分别给予1 mg非那雄胺(68例)、5%米诺地尔(74例)、1 mg非那雄胺和5%米诺地尔联合治疗(64例),疗程6个月。结果:治疗3个月时,联合治疗组有效率优于非那雄胺组。6个月时非那雄胺组、米诺地尔组及联合治疗组有效率分别为67.65%、62.16%和81.25%,联合治疗组优于米诺地尔组。脱发程度和病程不同者有效率差异均具有统计学意义(P<0.05)。结论:非那雄胺和米诺地尔联合治疗男性AGA起效较早,病程较短、脱发程度较轻、疗程较长者治疗效果较好。

Objectives：To compare the efficacy of lmg finasteride, 5% minoxidil alone and their combination in the treatment of male androgenetic alopeeia （AGA）. Methods： Male subjects with AGA grade Ⅲ ,Ⅳ and Ⅴ according to the Hamilton-Norwood scale were recruited. The subjects received continuous treatment for 6 months. For a total of 206 participants, 68 were given lmg finasteride, 74 were given 5% minoxidil and 64 were given the combination treatment of finasteride-minoxidil. Results： After 3 months of treatment, the degree of improvement of combination group was higher than that of finasteride group. After 6 months of treatment, the degree of improvement of finasteride, minoxidil and combination group were 67.65%, 62.16% and 81.25% respectively. The response in combination treatment group was higher than that of minoxidil group. There were significant differences in the degree of improvement in subjects with different degrees of hair loss or different courses （P 〈 0.05）. Conclusion： For patients with AGA, the combined therapy of finasteride-minoxidil works fast and those with longer treatment period, milder hair loss or shorter course respond more positively.