氟康唑、伊曲康唑、特比萘芬治疗系统性普通裂褶菌感染小鼠模型的观察

Therapy of Fluconazole,Itraconazole,Terbinafine in Mice Model with Systemic Infection of Schizophyllum commune

目的观察氟康唑、伊曲康唑、特比萘芬治疗系统性普通裂褶菌感染的疗效。方法建立小鼠系统性普通裂褶菌感染模型,观察给药后小鼠的生存率、中位生存时间、组织逆培养阳性率、肝脏组织载菌量。结果氟康唑组、伊曲康唑组、特比萘芬组、生理盐水对照组小鼠21d观察期内生存率分别为64.00%,68.00%,20.00%,12.00%;中位生存时间分别为>21d,>21d,11d和8d;肝脏组织逆培养阳性率分别为60.00%,68.00%,100.00%,100.00%;肝脏组织载菌量分别为19.533±4.121,20.706±5.193,32.920±8.485,36.520±9.138。结论氟康唑和伊曲康唑在小鼠体内均有较好的抗普通裂褶菌活性,而特比萘芬效果较差,氟康唑与伊曲康唑之间无疗效差别。

Objective To investigate the efficacy of Fluconazole, Itraconazole, Terbin tne for systemic infection of SchizophyUum commune in mice model. Methods Mice model suffered from systemic infection of Schizophyllum commune were established on and their survival rates, median survival time, Fungal retro-culture, fungal burden of liver of mice were observed after administration. Results During the observation period, the survival rates of Fluconazole group, Itraconazole group, Terbinafine group and control group were 64.00% ,68.00% ,20.00% ,12.00% respectively;the median survival time were 〉21d, 〉21d,lld and 8d; Fungal retro-cuhure of liver were 60.00% ,68.00% , 100.00%, 100.00% ; fungal burden of liver were 19. 533 ±4. 121,20.706±5. 193,32. 920± 8. 485,36. 520 ±9. 138. Conclusion Fluconazole and ltracon- azole show good activity against Schizophyllum commune in vivo, Terbinafine is ineffective in vivo. There are no significant difference between the therapy of Fluconazole and hraconazole .