系统性红斑狼疮228例临床分析

Clinical Study of 228 Patients with Systemic Lupus Erythematosus

目的探讨系统性红斑狼疮患者男女临床特点及预后。方法对228例系统性红斑狼疮住院患者进行回顾性分析。结果患者男25例,女203例,男女比例1:8.12,平均发病年龄(32.72±13.49)岁(6~71岁),平均病程(2.33±2.82)年(20d^10年);男性组肾脏损害、口腔溃疡、神经系统损害、血小板减少、抗Sm抗体阳性较女性组多见(P<0.05),而女性组则以蝶形红斑、关节受累、雷诺现象、抗SSA阳性较多见(P<0.05);经治疗女性组好转率(83.74%)较男性组(60.00%)高(P<0.05),死亡率(5.42%)则较男性组(16.00%)低(P<0.05)。结论 SLE患者男女临床表现、实验室检查及预后有一定差别,与女性相比,男性内脏损害发生率较高且预后较差,临床应引起重视。

Objective To study the clinical features and prognosis of systemic lupus erythenatosus between male and female （ MSLE and FSLE）. Methods Two hundred and twenty-eight SLE patients were collected and a retrospective analysis of the data was done. Result Twenty-five MSLE and 203 FSLE were investigated with a mean onset ages （ 32.72 ±13.49 ） （ 6 - 71 years ） and disease duration （ 2.33 ±2.82 ） （ 20days - 10years ）. Gender ratio was 1 ： 8.18. The damage of the kidney and central nervous system, oral ulcers, thrombocytope- nia and positivity of anti-Sm antibodies were more obvious in MSLE group. On the contrary, the malar rash, arthrodynia, Raynaud＇s phenomenon, anti-SSA antibodies were less in FSLE compared to those in male. Af- ter undergoing treatment, the improvement rate of male group（60.00% ） was lower than that of female group （ 83.74% ）, and the mortality rate of male group（ 16.00% ） was higher than that of female group（ 5.42% ）. Conclusion There＇s a difference in clinical symptoms, laboratory tests and prognosis between MSLE and FSLE. In MSLE the visceral injuries rate is higher and the prognosis is poorer. More emphasis should be laid down on these features of SLE patients.