摘要
危险信号分子,是一大类细胞结构蛋白,病理情况下释放到细胞外,通过启动和介导炎症反应,传递着细胞损伤的危险信号.以HMGB1、HSPs和S100为代表的危险信号分子,在肝脏慢性炎症和肿瘤形成的微环境中持续存在,在原发性肝癌形成和进展过程中发挥着重要的作用.危险信号分子可以成为新的预测和监测原发性肝癌发生、转移和复发的标志物,下调这些危险信号分子表达及阻断其与受体结合的措施,有望成为新的抗肿瘤治疗方法.
Alarmins are a kind of constitutive cellular proteins which are released extracellularly under pathological conditions to signal danger to the host by triggering and mediating inflammatory responses.Persistent release of alarmins（e.g.,HMBG1,HSPs and S100）during chronic liver inflammation and in tumor microenvironments plays an important role in the development and progression of liver carcinoma.Alarmins might become novel markers for predicting and monitoring carcinogenesis,metastasis and recurrence of liver carcinoma.Down-regulation of alarmins and blockage of the interaction of alarmins with their receptors represent new promising therapeutic strategies for liver carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第13期1326-1330,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30972621~~
关键词
危险信号分子
慢性炎症
原发性肝癌
Alarmins
Chronic inflammation
Primary hepatic carcinoma
