糖尿病合并甲状腺功能减退患者胃排空能力与幽门螺杆菌感染率的变化

Changes in gastric emptying ability and Helicobacter pylori infection rate in patients with diabetes mellitus and hypothyroidism

目的:观察糖尿病(DM)合并甲状腺功能减退患者胃排空能力与幽门螺杆菌(H.pylori)感染情况的变化.方法:96例受试者分成3组:正常组(健康体检者,30例)、DM组(45例)、DM并甲状腺功能减退组(21例),分别行消化道症状评分、胃排空时间及H.pylori感染情况测定,并加以对比.结果:DM并甲状腺功能减退组患者症状评分(分)、胃半排空时间(min)、胃全排空时间(min)显著高于正常组、DM组(12.67±3.10vs4.30±2.65,10.98±2.51;35.00±8.83vs25.53±4.83,29.76±9.54;60.57±15.65vs45.53±10.33,52.53±16.74,均P<0.05或0.01),同时3组患者H.pylori感染率逐渐升高(均P<0.05).结论:DM并甲状腺功能减退患者较单纯DM患者、健康体检者均胃排空能力明显下降,H.pylori感染率明显上升,更易发生胃肠功能障碍.

AIM：To investigate the changes in gastric emptying ability and Helicobacter pylori（H.pylori） infection rate in patients with diabetes mellitus （DM）and hypothyroidism.METHODS：Ninety-six subjects were divided into three groups：normal group（n=30）,DM group（n=45）,and DM plus hypothyroidism group（n=21）.The digestive tract symptoms,gastric emptying time and H.pylori infection rate were compared among the three groups.RESULTS：The grade of digestive tract symptoms,gastric half emptying time,and gastric emptying time were significantly higher in the DM plus hypothyroidism group than in the normal group and DM group（12.67±3.10 vs 4.30 ±2.65,10.98±2.51;35.00±8.83 vs 25.53±4.83,29.76±9.54;60.57±15.65 vs 45.53±10.33,52.53 ±16.74,all P0.05 or 0.01）.The rate of H.pylori infection was also significantly higher in the DM plus hypothyroidism group than in the other two groups（both P0.05）.CONCLUSION：Compared to normal controls and DM patients,DM patients with hypothyroidism had lower gastric emptying ability and higher H.pylori infection rate and were more susceptible to gastrointestinal dysfunction.