上海地区早发性乳腺癌临床病理特征分析

Clinicopathological Features of Early-onset Breast Cancer Patients in Shanghai

目的根据乳腺癌在我国早发的特点,分析上海地区早发性乳腺癌患者相关的重要临床病理学参数。方法研究对象为来自2000年后就诊长海医院和瑞金医院的乳腺癌患者,将发病年龄小于35岁定义为早发性乳腺癌,分析肿瘤大小、腋窝淋巴结转移数目、AJCC分期、组织学分级、ER和PR表达情况,Her-2表达情况以及分子分型、2009年St.Gallen乳腺癌专家共识分型之间的关系。结果通过分析后发现Her-2、肿瘤大小、组织学分级、分子分型(基底细胞样乳腺癌和管腔型B乳腺癌)、ER*PR共表达(ER+/PR-和ER-/PR+)与上海地区早发性乳腺癌(发病年龄<35岁时)关系密切。结论上海地区<35岁发病的早发性乳腺癌与发病年龄晚的乳腺癌不同,早发性乳腺癌组织学3级居多,ER/PR阳性率低与三阴乳腺癌和和管腔型B乳腺癌关系密切。

Abstract Objective The clinicopathological features of early - onset breast cancer in Shanghai were studied owing to earlier age at diagnosis in China. Methods We analyzed 2232 cases with invasive breast cancer in Changhai Hospital and Ruijin Hospital in Shanghai. Patients having breast cancers before 35 years were defined as early - onset breast cancers. The association between early - onset breas! cancer and other elinieopathologieal factors including tumor size, lymph node metastasis, AJCC stage, histologic grade, expression of ER, PR and Her- 2, molecular subtypes and international expert consensus on the primary therapy of early breast cancer in 2009 was ana- lyzed. Results The early - onset breast cancer was more likely to be high histologie grade, basal - like phenotype, luminal - B pheno- type and neither of ER/PR expression. Conclusion The early - onset breast cancer in Shanghai was characterized by higher histologic grade and more likely to be either basal - like or luminal - B phenotype and absent hormonal receptor expression.