地氟醚对数量化脑电图及血液动力学的影响

Effect of desflurane on quantitative electroencephalogram and hemodynamics

为观察地氟醚麻醉时数量化脑电图及血液动力学变化，评价两者用于监测地氟醚麻醉深度的可行性，选择美国麻醉医师学会（ Ａ Ｓ Ａ） 分级Ⅰ～Ⅱ级的择期手术患者８ 例，以异丙酚及万可松诱导后行气管内插管并吸入地氟醚。结果显示：地氟醚可使双频谱指数、９５ ％ 边缘频率和中间频率呈剂量相关性降低；呼气末地氟醚浓度达１５ Ｍ Ａ Ｃ（ 最低肺泡有效浓度） 时，平均动脉压显著下降，心率增快约１４５ ％ ，但无统计学意义。提示数量化脑电图可用于地氟醚麻醉深度监测，而 Ｍ Ａ Ｐ 和 Ｈ Ｒ 不是该药麻醉时理想的麻醉深度监测指标。

To evaluate the feasibility of monitoring depth of desflurane anesthesia by quantitative electroencephalogram(QEEG) and hemodynamics, eight ASA Ⅰ～Ⅱ patients were studied. Anesthesia was induced by propofol and vecuronium, after tracheal intubation and the lungs were ventilated with desflurane in oxygen. The results showed that desflurane significantly reduced bispectral index(BI), 95% spectral edge frequency(SEF) and median frequency(MF) in a negative linear dose related manner. When the end tidal desflurane concentration reached 1.5?MAC, mean artery pressure(MAP) was decreased significantly, and heart rate(HR) increased by 14.5%(but there was no statistic significance), compared with pre anesthesia. The results suggest that QEEG can be used to monitor depth of desflurane anesthesia, but MAP and HR are not the ideal monitoring indices during desflurane anesthesia.