摘要
测定５０ 例慢性肾功能衰竭（ Ｃ Ｒ Ｆ） 患者血浆脂蛋白（ａ）［ Ｌ Ｐ（ａ）］ 与组织型纤溶酶原激活物（ｔ Ｐ Ａ）及其抑制物（ Ｐ Ａ Ｉ） 活性，并与５０ 名健康人对照。结果表明： Ｃ Ｒ Ｆ 患者血浆 Ｌｐ（ａ） 浓度明显升高，ｔ Ｐ Ａ 活性明显降低； Ｌｐ（ａ） 与血浆尿素氮水平，２４ ｈ 尿蛋白量及尿蛋白浓度成正相关；与ｔ Ｐ Ａ 活性成负相关。提示肾功能对血浆 Ｌｐ（ａ） 浓度起一定的调节作用， Ｌｐ（ａ） 水平的升高可能与纤溶损伤有关。
Plasma Lp(a) concentration and activiation of tissue type plasminogen activator(t PA) and plasminogen activator inhibitor 1(PAI 1) were determined in 50 patients with chronic renal failure(CRF) and in 50 healthy subjects. The results demonstrated that plasma concentration of Lp(a) was significantly higher and plasma t PA activation was significantly lower in CRF patients than in healthy subjects. With multivariate analyses, plasma Lp(a) concentration was positively correlated with the total amount of 24?h uric protein, plasma BUN and uric protein concentration. Moreover, a negative signficant correlation between plasma Lp(a) levels and t PA activation was observed. Plasma Lp(a) levels did not show a correlation to PAI 1 activation. It is indicated that renal function may contribute to moderate plasma Lp(a) concentration and elevated Lp(a) levels may be related with fibrinolytic impirment.
出处
《湖南医科大学学报》
CSCD
1999年第4期366-368,共3页
Bulletin of Hunan Medical University
关键词
肾功能衰竭
脂蛋白A
T-PA
PAI
chronic renal failure
Lipoprotein(a)
tissue type
plasminogen activator
plasminogen activator inhibitor
