急性肝炎、肝硬化患者血清一氧化氮与免疫细胞因子的关系

Relationship of nitric oxide and immunal function of the patients with acute hepatitis and hepatic cirrhosis

对９０ 例急性肝炎、肝硬化患者及健康人血清中 Ｉ Ｌ１２ ， Ｉ Ｌ１０ ， Ｔ Ｎ Ｆα和 Ｎ Ｏ 水平进行检测。结果证明，急性肝炎患者血清中 Ｉ Ｌ１２ ， Ｉ Ｌ１０ 和 Ｎ Ｏ 水平与健康人接近；而 Ｔ Ｎ Ｆα的水平明显增高。肝硬化患者血清中 Ｉ Ｌ１２ ， Ｉ Ｌ１０ ， Ｔ Ｎ Ｆα和 Ｎ Ｏ 水平较健康人显著增高。提示肝硬化患者的免疫功能紊乱与 Ｎ Ｏ升高有关。

The interleukin 12(IL 12), interleukin 10(IL 10), tumor necrosis factor(TNF) and nitric oxide(NO) levels in serum of 90 patients with hepatitis and cirrhosis were measured by the method of ELISA and colorimeter. The levels of IL 12, IL 10 and NO in serum of the patients with hepatits were in close proximity to the level of healthy control, but the TNF level was significantly higher than that of healthy control. The IL 12, IL 10, TNF and NO levels in serum of the patients of hepatic cirrhosis were significantly higher than that of healthy control and patients with hepatits. The results suggested that the NO level was not related with the hepatic damage of acute hepatitis. The dysfunction of immunology in the patients with cirrhosis was related with the increase of NO level.