血浆内皮素和一氧化氮与肾性高血压及肾机能的关系

Study on the relationship between plasma endothelin nitric oxide concentration and renal hypertension and renal function

采用放射免疫及生化方法测定６０ 例肾脏病患者血浆 Ｅ Ｔ 和 Ｎ Ｏ 浓度，并进行相关分析。结果示：①肾脏病组血浆 Ｅ Ｔ１ 浓度高于正常对照组（ Ｐ ＜ ０ ．０１） ；血浆 Ｎ Ｏ 浓度低于正常对照组（ Ｐ ＜ ０ ．０１） 。②高血压组患者血浆 Ｅ Ｔ 高于非高血压组（ Ｐ ＜ ０ ．０１） ，血浆 Ｎ Ｏ 低于非高血压组（ Ｐ ＜ ０ ．０１） 。③肾机能不全组血浆 Ｅ Ｔ 高于肾机能正常组（ Ｐ ＜ ０ ．０１） ，血浆 Ｎ Ｏ 低于肾机能正常组（ Ｐ ＜ ０ ．０５） 。④ Ｅ Ｔ 分别与血压、 Ｂ Ｕ Ｎ 及 Ｓｃｒ 呈正相关， Ｎ Ｏ 分别与血压、 Ｂ Ｕ Ｎ 及 Ｓｃｒ 呈负相关。提示血浆 Ｅ Ｔ 及 Ｎ Ｏ 可能参与肾性高血压的病理生理过程。

To investigate the relationship between plasma endothelin(ET), nitric oxide(NO) levels and, renal hypertension and renal function. Methods: The plasma concentration of ET 1 was detected by immunofluorescence assay. The plasma concentration of NO was detected by biochemistry assay. Results: ① In renal disease patients, plasma concentration ET 1 was markedly elevated, and plasma concentration of NO was decreased, compared with the healthy subjects(P<0.01). ② Plasma concentration of ET 1 was markedly increased and plasma concentration of NO was decreased in the patients with renal hypertension. ③ Plasma level of ET 1 was higher, and plasma level of NO was lower in the patients with renal function damage than that of those without renal function damage. ④ BP, BUN and Scr were positively correlated with plasma ET 1, but they were negatively correlated with plasma concentration of NO. Conclusion: Plasma ET 1 and NO may play an important role in pathogenesis of renal hypertention; the change of their levels may be related to the progress of these renal diseases.