江苏省不同糖耐量人群代谢综合征的患病率研究

Prevalence of metabolic syndrome in Jiangsu adults with different glucose tolerance

目的比较江苏省不同糖耐量人群代谢综合征(MS)的患病率。方法采取整群随机抽样方法,内容包括体检、75g葡萄糖耐量试验(OGTT)及检测血脂等,并根据OGTT结果分为正常糖耐量(NGT)组、糖调节受损(IGR)组和2型糖尿病(T2DM)组。结果 (1)NGT组、IGR组和T2DM组的MS的患病率分别为16.3%、47.6%及64.6%。(2)T2DM组女性MS患病率显著高于男性(72.6%vs53.1%),而NGT组及IGR组MS患病率男女之间无统计学差异(IGR组:53.9%υs39.8%;NGT组:16.7%υs15.7%)。(3)从NGT→IGR→T2DM,MS患者中合并3种MS组分者的比例逐渐减少,而合并4种及5种MS组分者的比例逐渐增多。结论在T2DM前期IGR阶段,MS患病率已经显著升高;T2DM患者常合并多种代谢异常,是MS的高发人群。

Objective To study the prevalence of metabolic syndrome （MS） in Jiangsu adults with different glucose tolerance. Methods With randomized cluster sampling, physical examination, 75g oral glucose tolerance test and blood lipids measurement were performed in people from five cities of Jiangsu province. The study subjects were then divided into normal glucose tolerance group （NGT）, impaired glucose regulation group（IGR） and type 2 diabetes mellitus group（T2DM） according to the results of OGTT. Results （1） The MS prevalence in NGT group, IGT group and T2DM group were 16.3%, 47.6% and 64.6% respectively. （2） The MS prevalence was higher in female than in male of T2DM group （72.6% vs 53.1%, P〈0. 05）, while there was no significant difference in MS prevalence between male and female population in IGR versus NGT group（53.9% vs 39.8%） and （16.7% vs 15.7%）. （3） From NGT to IGR to T2DM, constituent ratio of people with 3 MS components decreased gradually, while constituent ratio of people with 4 or 5 MS components increased gradually. Conclusions The MS prevalence increases significantly in prediabetes. Type 2 diabetic patients are often associated with a variety of metabolic abnormalities, and have a high risk of MS.