肝硬化上消化道出血医院感染患者预防性应用抗菌药物的观察

Clinical effect of prophylactic use of antibiotics on nosocomial infection in cirrhotic patients with gastrointestinal hemorrhage

目的探讨预防性应用抗菌药物对肝硬化上消化道出血患者医院感染的影响和安全性。方法将100例患者随机分成观察组和对照组,各50例,观察组预防性应用抗菌药物,对照组不用抗菌药物,观察比较两组患者医院感染率、再出血率和住院时间等。结果观察组患者医院感染率为14.0%,再出血率为24.0%,住院时间(15.4±3.1)d,明显好于对照组,其医院感染率、再出血率及住院时间分别为38.0%、46.0%及(20.4±4.3)d,差异有统计学意义(P<0.05)。结论肝硬化上消化道出血患者预防性应用抗菌药物,可以降低医院感染率和再次出血率,缩短住院时间,值得临床推广应用。

OBJECTIVE To explore the clinical effect and safety of preventing usage of antibiotics on the nosocomial infection of cirrhotic patients with gastrointestinal hemorrhage.METHODS A total of 100 cases patients were randomly divided into the intervention group（50 cases） and control group（50 cases）;The intervention group was used antibiotics,the control group without antibiotics.The rates of nosocomial infection and re-bleeding,hospital time were observed and compared.RESULTS The rate of nosocomial infection was 14.0%,the rate of re-bleeding was 24.0%,hospital time was 10.4±3.1 d in the intervention group were better 38.0%,46.0% and 15.4±4.3d in the control group,there were significant differences（P〈0.05）.CONCLUSION The preventing use antibiotics on cirrhotic patients with gastrointestinal hemorrhage can reduce the rates of nosocomial infection and re-bleeding,shorten the time of hospital stay,and hence is worthy of being recommended in clinical practice.