CEA和CA724联合检测在结直肠癌诊断中的应用

Application of combined determination of CEA and CA724 in the diagnosis of colorectal cancer

目的:探讨癌胚抗原(CEA)和糖链抗原724(CA724)联合检测对结直肠癌的诊断价值。方法:用化学发光法检测结直肠癌患者41例、结直肠良性病变患者46例、健康体检人群101例的血清CEA含量,用电化学发光法检测3组人群的血清CA724水平,统计分析CEA和CA724在结直肠癌诊断中的应用价值。结果:结直肠癌患者血清CEA和CA72-4水平显著高于结直肠良性病变患者及健康体检人群的水平(P<0.05),结直肠良性病变患者血清CEA和CA72-4浓度显著高于健康体检人群的浓度(P<0.05)。单项检测CEA对结直肠癌诊断的敏感度、特异度和准确度分别为58.5%、76.0%、67.8%,CA724为34.1%、93.4%、65.5%;联合检测CEA和CA724为68.2%、71.7%、70.1%。结论:CEA和CA724对结直肠癌诊断和疗效监测有一定价值,两者联合检测可提高结直肠癌的检出率。

Objective To investigate the diagnostic value of combined determination of CEA and CA724 for eoloreetal cancer. Methods Serum levels of CEA in 41 patients with eoloreetal cancer,46 patients with benign colorectal diseases,and 101 healthy controls were measured by chemolumineseence assay,and serum levels of CA724 in the three groups were detected by electroehemolumineseenee assay. The diagnostic value of CEA and CA724 for eoloreetal cancer was analyzed. Results Serum levels of CEA and CA724 in patients with eoloreetal cancer were significantly higher than those in patients with benign colorectal diseases and healthy controls （P 〈 0.05）. And those in patients with benign coloreetal diseases were significantly higher than those in healthy controls （P 〈 0.05）. The sensitivity, specificity, and accuracy of CEA for the diagnosis of colorectal cancer were 58.5%, 76.O%, and 67.8%, respectively; those of CA724 were 34.1%, 93.4%, and 65.5%, respectively; and those of combined detection of CEA and CA724 were 68.2% ,71.7% ,and 70.1% ,respectively. Conclusion There are certain values of detection of CEA and CA724 for the diagnosis and effects-monitoring in colorectal cancer. Combined determination of CEA and CA724 was helpful to increase the detection rate of colorectal cancer.