溴化异丙托品不同吸入方法对COPD患者支气管扩张功能的影响

BRONCHODILATING EFFECTS IN COPD AFTER INHALING IPRATROPIUM BROMIDE WITH DIFFERENT PATTERNS OF NEBULIZATION RESPECTIVELY

目的：评价定量、喷射、手控雾化3种方法吸入溴化异丙托品对COPD患者的疗效。方法：按病情将25例住院患者分为急性发作期组、慢性迁延期组，吸入溴化异丙托品后4h内观察肺通气功能的变化。结果：吸入溴化丙托品后，患者的肺活量（VC）、V50。V25无明显变化；急性期患者FVC％，FEV1％，Vmax％上升值以手控雾化最高，喷射雾化次之，定量雾化最低；慢性迁延期患者FVC％，FEV1％，Vmax％上升值定量雾化与喷射雾化相近，手控雾化明显高于前两者。结论：定量雾化仅适用于慢性迁延期COPD患者，手控雾化和喷射雾化对于急性发作期及慢性迁延期COPD患者均适用，且手控雾化疗效最佳。

To estimate the therapy effect of inhaling ipratropium bromide (Atrovnt) withmetered inhaler, jet - nebulinzer, and hand - hold nebulizer respectively. Methods: Pratropium bromidewas in haled by the randomed, self - controled, single - blinded trail in 25 inpatients with chronic obstructive pulmonary disease (COPD) who were divided into two groups - COPD in acute phase and COPD instable phase. Four - hour lung function was recorded after inhaling ipratropium bromide. Result: Afterinhaling ipratropium bromide, no significant change was found in VC, V50, V25, On the increase ofFVC%, FEV1%, Vmax% of COPD in acute phase, hand - hold nebulizer was significantly higher thanjet - nebulizer, metered does inhaler was the lowest, those in stable phase, metered dose inhaler was similar to jet - nebulizer and hand - hold nebulizer was significantly higher. Conclusion: Metered dose inhaleris only good for COPD in stable phase, hand - hold nebulizer and jet - nebulizer are both good for COPD inacute or stable phase and hand - hold nebulizer is better.