五参安神胶囊对大鼠慢性应激抑郁模型的影响

The influence of Wushen Anshen capsules on the rat chronic stress despondent model

目的探讨五参安神胶囊对慢性应激抑郁模型大鼠的行为学、体重、液体与糖水消耗的干预作用。方法将60只♂SD大鼠随机均分为正常组、模型组、氟西汀组和五参安神胶囊大、中、小剂量组。采用长期轻度不可预见性应激+孤养复制大鼠抑郁模型,观察大鼠体重和摄食量的变化,用敞箱实验及液体消耗实验测定大鼠的行为。结果模型组大鼠的体重增加量、摄食量、敞箱实验得分、糖水消耗均明显下降,纯水消耗显著提高;氟西汀组和五参安神胶囊大、中剂量组抑郁模型大鼠的各种症状均有较大程度改变。结论五参安神胶囊对慢性应激抑郁模型大鼠的行为学、体重、液体消耗及糖水消耗具一定调节作用。

OBJECTIVE To discuss the changes of praxiology,weight,liquid consumption and sugar consumption in chronic stress depression rat model,and the intervention by Wushen Anshen capsule.METHODS Sixty SD male rats were randomly divided into normal control group,model control group,fluoxetine control group and Wushen Anshen capsule＇s large,medium and small dose groups 10 each group.The rat model of depression was established by using long-term unpredictable mild stress and being singly housed.The method was used to observe the changes of animal＇s body weight and food intake,with the open field experiment and liquid consumption experiment to determine the animal behavior.RESULTS In model group,weight gained,food intake,open field test scores and sugar consumption were significantly decreased,but water consumption increased significantly.In Fluoxetine group and Wushen Anshen capsule＇s high and mendium dose group,depression symptoms of rat model had signifiant change.CONCLUSION Wushen Anshen capsules has regulatoty effect on changes of behavior,body weight,fluid consumption and sugar consumption in rat model of chronic stress.