颅内与颅外动脉重度狭窄或闭塞患者血管危险因素的差异

The differences of risk factors between intracranial and extracranial high-grade atherosclerotic stenosis or occlusion

目的探讨颅内与颅外动脉重度狭窄或闭塞患者常见血管危险因素的差异。方法选择诊断颅内外动脉重度狭窄或闭塞的患者235例,根据病变血管部位分为单纯颅外组111例,单纯颅内组97例及混合组27例。回顾分析3组患者常见血管危险因素的差异。结果单纯颅外组平均年龄明显高于混合组和单纯颅内组(P<0.05,P<0.01),高脂血症比例和尿酸水平明显低于单纯颅内组,血小板聚集率明显高于单纯颅内组(P<0.05)。混合组糖尿病比例和纤维蛋白原明显高于单纯颅内组(P<0.05)。logistic回归分析显示,年龄和尿酸是男性颅内动脉重度狭窄或闭塞的独立危险因素。结论颅内与颅外动脉重度狭窄或闭塞患者的血管危险因素存在差异。

Objective To evaluate the differences of common risk factors between high-grade intracranial and extracranial atherosclerotic stenosis or occlusion in middle aged and old patients. Methods 235 patients with high-grade atherosclerotic stenosis or occlusion on duplex ultrasound were included. They were divided into only-extracranial group （n = 111）, only-intracranial group （n = 97） and mixed group （n = 27） according to the location of high-grade atherosclerotic stenosis or occlusion. The common risk factors in three groups were compared. Results There was significant difference in average ages among the three groups：only-intracranial group 〈mixed group 〈only-extracranial group. The value of platelet aggregation test was higher in only-ex- tracranial group than in only-intracranial group, but the percentage of hyperlipemia and the level of serum uric acid were lower （P 〈0.05 ,P〈 0.01）. The percentage of diabetes and the level of fibrinogen were higher in mixed group than in only-intracranial group （P 〈 0.05）. The serum uric acid was an independent risk factor for high-grade intraeranial atheroselerotic stenosis or occlusion in male patients. Conclusion The results indicated that there were differences of common risk factors between high-grade intracranial and extracranial atherosclerotic stenosis or occlusion.