摘要
目的:考察马洛替酯在大鼠体内肠吸收机制。方法:采用大鼠在体单向灌流法进行肠吸收实验,利用高效液相色谱法测定灌流流出液中马洛替酯的浓度,按重量法计算动力学参数。结果:马洛替酯在十二指肠、空肠、回肠和结肠的吸收速率常数(Ka)、有效渗透系数(Peff)差异均有统计学意义(P<0.05);供试液的浓度对十二指肠的Ka值和Peff值差异无统计学意义(P>0.05)。结论:马洛替酯在大鼠体内肠吸收机制为被动扩散,不存在饱和吸收,且以肠道中上部的吸收为主。
Objective：To investigate the mechanism of malotilate intestinal absorption in rats.Methods：Intestinal absorption experiment was performed by in vivo single-pass perfusion.The efflux fluid was collected and weighed,and the concentration of malotilate in the perfusate was determined by HPLC.Gravimetric method was used for calculation of kinetics parameter.Results：The absorption rate constant（Ka） and apparent absorption coefficient（Peff） of malotilate over duodenum,jejunum,ileum and colon were different between them（P0.05）.Concentration had no effect on the Ka and Peff（P0.05）.Conclusion：The mechanism of malotilate intestinal absorption in rats was passive diffusion,and there was no saturated absorption.Malotilate was well absorbed at the superior and middle segments of intestine in rats.
出处
《抗感染药学》
2011年第2期100-103,共4页
Anti-infection Pharmacy
关键词
马洛替酯
单向灌流肠吸收
吸收速率常数
有效渗透系数
malotilate
single-pass intestinal perfusion
absorption rate constant
apparent absorption coefficient
