槟榔碱与灭螺药物合用的增效作用研究

STUDIES ON SYNERGIC EFFECT OF ARECOLINE IN COMBINATION WITH SNAIL-KILLING DRUGS

目的证明槟榔碱与灭螺药物合用的增效作用。方法采用WHO公布的“杀螺剂实验室终筛法”中的浸泡法。结果在0．125mg／L氯硝柳胺和1．25mg／L五氯酚钠的药液中，分别加入槟榔碱100mg／L，其24h钉螺开厣率由47．8％和13．3％，升至66．7％和83．3％；1h上爬附壁率，由81．1％和92．2％，下降至35．0％和30．0％；死亡率由1．1％和3．3％，增加到66．7％和100％（P＜0．01）。结论槟榔碱与化学灭螺药合用后，降低了钉螺对药物刺激的敏感性，钉螺上爬率明显降低，灭螺效果显著增强，从而证明了槟榔碱具有降低化学灭螺药的剂量，抑制钉螺上爬，增强灭螺效果的作用。

Objective To prove that arecoline (Are) combination with snail-killing drugs can increase the effect of snail-killing. Methods Immersing method of 'Final screen method in lab of snail-killing drugs' issued by WHO. Results After adding 100 mg/L Are to 0. 125mg/L niclosamide and 1. 25mg/L NaPCP separately,the rate of opening operculum for 24 hours increases from 47. 8%, 13. 3% to 66. 7%, 83. 3%, the rate of climbing adhesion for 1 hour decreases from 81. 1%, 92. 2% to 35. 0%, 30. 0%, the rate of death increases from 1. 1%, 3. 3% to 66. 7%,100%(P<0. 01). Conclusions Are itself has snail-killing effect. After adding it to low concentration of chemical snail-killing drugs,the rate of climbing adhesion decreases,the rates of opening operculum and death obviously increase.