日本杉特异性IgE,IgG亚类在鼻变态反应中的诊断意义

Specific IgE and specific IgG subclasses in allergic rhinitis

观察120例日本杉花粉过敏鼻炎病人的总IgE，特异性IgE，总IgG及特异性IgG亚类水平。结果表明，病人特异性IgE（30．60±0．78iu／ml）明显高于对照组（0.64±0．16iu／ml）（p＜0．01），特异性IgG4水平，病人组（478．88±120．60ng／ml）与对照组（284．90±118．10ng／ml）亦有显著差异（P＜0．01），特异性IgG2比较也有显著差异（病人组457．46±136．65ng／ml，对照组203．44±110．70ng／ml）（P＜0．01），治疗后病人组特异性IgE水平下降（治疗前30．60±0．78iu／ml，治疗后1．58±0．44iu／ml，P＜0．01），特异性IgG4水平也下降（治疗前478．88±120．60ng／ml，治疗后292.10±101．18ng／ml，P＜0．01），均存在显著差异，提示特异性IgG亚类在Ⅰ型变态反应的诊断作用中具有明显的特异性及敏感性。

Using enzyme-linked immunosorbent assay,we detected the levels of total IgE,Japanese cedar specificIgE,and Japanese cedar specific IgG subcalass in 120 patients with Japanese cedar allergic rhinitis.The resultsshowed that the levels of SIgG4(478.88±120.60ng/ml) of patients were significantly higher than those of thecontrols(P＜0.01),and the same results were found for concentrations of specific IgG2 and IgG4.The differecebetween before-treatment and after-treatment levels of specifie IgE and specific IgG4 was also significant(specific IgE before treatment.30.60±0.78iu/ml,after treatment:1.58±0.44iu/ml P＜0.01,specific IgG4 before treat.mentt478.88±120.60ng/ml,after treatment.292.10±101.18ng/ml P＜0.01).We conclude that specific IgG subclasseshave obvious etiological specificity and sensitivity.