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血管紧张素受体阻滞剂在冠状动脉支架置入术后再狭窄中的研究进展

Research Progress in Using Angiotensin Ⅱ Receptor Blockers in Restenosis Prevention after Percutaneous Coronary Interventions
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摘要 随着冠状动脉支架置入术的深入开展,支架置入术后再狭窄受到更多关注。肾素-血管紧张素系统在支架内再狭窄的发生中具有重要作用。血管紧张素受体选择性的不同,直接参与支架内再狭窄的发展。通过对于血管紧张素受体的选择性阻断,可延缓支架置入术后冠状动脉再狭窄的程度,对预防冠状动脉支架置入术后再狭窄具有重要意义。 With the development of coronary stent implantation,research has revealed the mechanisms of restenosis and has determined how to eliminate this event.The renin-angiotensin system may play an important role in the development of in-stent restenosis.Angiotensin receptor blockers,due to angiotensin Ⅱ receptor selection,reduce proliferation of vascular smooth and neointimal formation.This review examines progress made in the research of the angiotensin Ⅱ receptor blockers in restenosis prevention after percutaneous coronary interventions.
作者 黄成磊 施海明
机构地区 复旦大学附属华山医院心内科
出处 《心血管病学进展》 CAS 2011年第3期340-343,共4页 Advances in Cardiovascular Diseases
关键词 冠状动脉支架内再狭窄 肾素-血管紧张素系统 血管紧张素受体抑制剂 in-stent restenosis renin-angiotensin system angiotensin receptor blocks
分类号 R541.4 [医药卫生—心血管疾病]
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  • 1Fischman DL, Leon MB, Bairn DS, et al. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators [ J ]. N Engl J Med, 1994, 331 (8) : 496-501.
  • 2Lemos PA, Serruys PW, van Domburg RT, et al. Unrestricted utilization of sirolimus-eluting stents compared with conventional bare stent implantation in the "real world": the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry [ J ]. Circulation, 2004, 109 (2) : 190-195.
  • 3Schindler C, Mueller A, Bramlage P, et al. Comparison of selective AT1-receptor blockade versus ACE inhibition for restenosis prophylaxis in patients with peripheral occlusive arterial disease after stent angioplasty: a randomized, controlled, proaf-of-eoncept study[ J ]. Angiology, 2007, 58 (6) : 710-716.
  • 4Browatzki M, Larsen D, Pfeiffer CA, et al. Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox-sensitive manner [ J ]. J Vasc Res, 2005, 42(5): 415-423.
  • 5Bouallegue A, Vardatsikos G, Srivastava AK. Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1-and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells[J]. Can J Physiol Pharmacol, 2009, 87(12) : 1009-1018.
  • 6Andreozzi F, Laratta E, Seiaequa A, et al. Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-I on Ser312 and Set616 in human umbilical vein endothelial cells[J]. Circ Res, 2004, 94(9) : 1211-1218,.
  • 7Suzuki H, Motley ED, Frank GD, et al. Recent progress in signal transduction researeh of the angiotensin II type-1 receptor: protein kinases, vascular dysfunction and structural requirement[ J]. Curr Med Chem Cardiovasc Hematol Agents, 2005, 3(4): 305-322.
  • 8Ohtsu H, Suzuki H, Nakashima H, et al. Angiotensin II signal lransduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells [ J ]. Hypertension, 2006, 48 (4) : 534-540.
  • 9Adachi Y, Saito Y, Kishimoto I, et al. Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice[JJ. Circulation, 2003, 107( 19): 2406-2408.
  • 10Cui T, Nakagami H, Iwai M, et al. Pivotal role of tyrosine phosphatase SHP- 1 in ATz receptor-mediated apoptosis in rat fetal vascular smooth muscle cell [J]. Cardiovasc Res, 2001, 49(4) : 863-871.
心血管病学进展
2011年 第3期

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