醛固酮受体拮抗剂治疗心房颤动的研究进展

Advances in Treating Atrial Fibrillation with Aldosterone Receptor Antagonist

心房颤动是临床上最常见的持续性心律失常,近年来研究表明心房重构是心房颤动发生和维持的中心环节,心房重构包括电重构和结构重构,然而心房重构确切的机制尚未完全明确。近年来的研究表明,醛固酮与心房重构有着密切的关系。文章综述了醛固酮影响心房重构的机制以及醛固酮受体拮抗剂治疗心房重构的研究。

Atrial fibrillation（Af） is the most common sustained arrhythmia in the clinical setting.It has been demonstrated that atrial remodeling,which includes atrial electrical remodeling and structural remodeling,is the primary contributor to the development and self-perpetuating of Af.However,not all of the mechanisms that underlie the atrial remodeling process in Af have been found.This article summarizes the relationship between aldosterone and atrial remodeling and the aldosterone receptor antagonist treatment of atrial remodeling.