幽门螺杆菌感染与小儿胃十二指肠疾病的关系

Relationship between Hp infection and gastroduodenal diseases in children

目的 研究幽门螺杆菌（ Ｈｐ） 感染与小儿慢性胃炎、消化性溃疡病之间的关系，探讨 Ｈｐ的致病性。方法 我们对经胃镜检查证实的２４５ 例非溃疡性消化不良与６３ 例消化性溃疡患儿胃镜取材做 Ｈｐ 培养、快速尿素酶试验、病理学检查及血清 Ｈｐ Ｉｇ Ｇ 抗体测定。结果 在５６ 例十二指肠溃疡中 Ｈｐ 感染率为８３ ．９３ ％ ，７ 例胃溃疡为２８ ．５７ ％ ，２２４ 例慢性浅表性胃炎为４９ ．１１ ％ ，１１ 例慢性萎缩性胃炎为９０ ．０１ ％ ，其中３３ 例慢性活动性胃炎为９６ ．９７ ％ ，轻度胃炎为３２ ．７０ ％ ，中度胃炎为８３ ．７８ ％ ，而１０ 例正常胃粘膜者无１ 例发现 Ｈｐ 。结论 Ｈｐ 感染与小儿胃十二指肠疾病密切相关，尤其是活动性胃炎和十二指肠溃疡。

Objective To ascertain the relationship between Hp infection and gastroduodenal di sease . Methods 245 cases of F Dand 63 cases of peptic ulcer with age range 2 ～14 years old were studied . In pediatric patients, biopsies were taken fro m the antrum and Hp studies were carried out (culture ,ureasetest, Warthan Starry silver and Hp Ig Gantibody . Results Hp was present in 83 .92 % of 56 duodenal ul cers ,28 .57 % of 7 gastric ulcers, 49 .11 % of 224 chronic gastritis . Among the latter ,active gastritis was96 .96 % and atrophic gastritis 90 .97 % . Classified by severity of gastritis , we foundin mild gastritisit was32 .70 % ,in m oderate gastritis 83 .78 % ,10 cases with normal gastric m ucosa were all Hp negative . Con clusion Children’s chronic gastric disease , particularly with active gastritis and duodenal ulcer werestrongly associated with Hp .( Shanghai Med J, 1999 ,22∶466 468)