Bcl-2和P53蛋白在胃肠道粘膜相关淋巴组织淋巴瘤中的表达及其临床意义

Expression of oncoproteins Bcl 2 and P53 in patients with gastrointestinal m ucosa associated ly mphoid tis sue lym phom a and their clinical significances

目的 通过 Ｂｃｌ２ 和 Ｐ５３ 蛋白在胃肠道粘膜相关淋巴组织（ Ｍ Ａ Ｌ Ｔ） 淋巴瘤中的表达，探讨它们与肿瘤恶性程度及预后的关系。方法 收集我院１９９０ 年１ 月到１９９７ 年１２ 月胃肠道 Ｍ Ａ Ｌ Ｔ淋巴瘤２４ 例，行常规 Ｈ Ｅ 和 Ｌ Ｓ Ａ Ｂ 法免疫组化染色， Ｄ Ａ Ｂ 染色，苏木素复染。结果 ２４ 例均为 Ｂ 细胞型 Ｍ Ａ Ｌ Ｔ 淋巴瘤，属低度恶性１６ 例（ 占６６ ．７ ％ ） ，高度恶性８ 例（ 占３３ ．３ ％ ） 。 Ｂｃｌ２ 表达阴性１６例，阳性８ 例。 Ｐ５３ 蛋白表达呈阴性和阳性者各１２ 例。 Ｂｃｌ２ 在低度和高度恶性 Ｍ Ａ Ｌ Ｔ 淋巴瘤中的表达及在不同预后患者中的表达均有差异。 Ｐ５３ 则均无差异。结论 Ｂｃｌ２ 对判断胃肠道 Ｍ Ａ Ｌ Ｔ 淋巴瘤的恶性程度和预测预后均有帮助。 Ｐ５３ 表达与胃肠道 Ｍ Ａ Ｌ Ｔ 淋巴瘤的恶性程度和是否伴有淋巴转移均无关。

Objective To investigate therelationship of Bcl 2 and P53 expressions to the histologicalgrading and prognosis in patients with gastrointestinal M A L Tlym phoma . Methods 24 cases with gas trointestinal M A L Tlym phom a from 1990 to 1997 in our hospital were studied with H Eand im m unohisto chemicalstaining . Results All cases were B cell M A L Tly mpho mas. Among them 16 cases were of high grade ,8 low grade . Bcl 2 expression was positive in 16 and negative in 8 . P53 expression was positive andnegativein 12 cases each . The Bcl 2 expression varied in M A L Tly mpho ma patients with high and lowgrade maligancy ,the prognosis was also different ,but no difference was found in P53 expression . Conclusion Bcl 2 is usefulin determining the malignant grading of gastrointestinal M A L Tly m pho ma and in predict ing the prognosis while P53 is not .( Shanghai Med J,1999 ,22 :469 471)