3[1]TongS,Kim KH,ChanteC,et al.Hepatitis B virus e antigen variants[J].Int J Med Sci,2005,2(1):2-7.
4[4]Hasegawa K,huang JK,Wands JR,et al.Association of hepatitis Bviralprecore mutations with fulminant hepatitis B in Japan[J].virology,1991,185(1):460-463.
5[6]Albert A.Do single nucleotide mutation result inclinically significant changes in hepatitis B virus pathogenicity[J].J Hepatol,1990,10;268.
6[7]Chen M,Sallberg M,Hughes J,et al.Immune tolerance split between hepatitis B virus precore and core proteins[J].J Virol,2005,79(5):3016-3027.
7Foster G R, Thomas H E. Recent advances in the molecular biology ofhepatitis B virus; mutant virus and the host immune response[J]. Gut, 1993;34:1
8Goergen B, Meyer-Zum-Bueschenfeld K H, G erken G. Mutation specific PCR and direct solid phase sequencing assay for the detection of hepatitis B virus prec/c mutants in anti-HBe-positive, chronic hepatitis B[J].J Med Virol. 1994;43:97
9Allberi A, Chemello L, Fattorich G et al. Serum levels of soluble inter lukin-2 receptors in acute and chrofic viral hepatitis[J]. Dig Dis Sci,1989;34(10): 1559
10Mondeli M, Vergani G M, Alberti A et al. Specificity of T-Lymphocyte cytotoxicity to autologous hepatocytes in cbronic hepatitis B virus infeetion: evidence that T-cell are directed against HBV core antigen expressed on hepatocytes[J] .J Immunol, 1982; 129(6) :2773