氟苯尼考琥珀酸钠抗菌活性研究

Antibacterial Activity of Florfenicol Sodium Succinate

研究氟苯尼考琥珀酸钠在体内转化后的抗菌效果,为临床前给药提供一定的理论依据。用微生物法,以抑菌圈直径为指标,考察氟苯尼考琥珀酸钠(前药)转化后对敏感菌的抗菌活性。给大鼠按30 mg/kg肌注前药1 h后,可以达到最大血药浓度4.0μg/mL,与氟苯尼考(母药)的抗菌活性相当。氟苯尼考琥珀酸钠在大鼠体内能够迅速转化为母药而发挥其抗菌活性。

Antibacterial effects of florfenicol sodium succinate（F-S-Na） in vivo conversion was studied to provide a certain theoretical basis for potential preclinical administration.Diameter of inhibitory ring of microbiological method was used as an index to observe the antibacterial activity of F-S-Na（produg） after being converted.The results showed that Cmax of hemato-medicine was 4.0 μg/mL 1 h after i.m administration according to 30 mg/kg,and its antibacterial activity was about the same as florfenicol.Therefore F-S-Na could be rapidly converted to parent medicine and give scope to its antibacterial activity.