罗库溴铵、阿曲库铵和琥珀酰胆碱三药肌松作用的对照研究

Neuromuscular Blockade Action of Rocuronium Compared to Atracurium and Succinycholine

全麻下组Ⅰ以罗库溴铵０ ．６ ｍｇ／ｋｇ 静注，组Ⅱ以阿曲库铵０ ．５ ｍｇ／ｋｇ 静注，组Ⅲ以琥珀酰胆碱１ ．５ ｍｇ／ｋｇ 静注。结果：气管插管条件，以琥珀酰胆碱组肌松作用最好，而罗库溴铵和阿曲库铵肌松作用相似；罗库溴铵组肌松起效时间、临床恢复时间和无反应时间分别为８６ ．２５ ±２７ ．１３ｓ 、２９ ．９０ ±６ ．２５ ｍｉｎ 和２０ ．８４ ±７ ．９５ ｍｉｎ ，介于其它两药之间。说明，罗库溴铵可为临床提供较好的气管插管条件，且无琥珀酰胆碱的诸多副作用。

Method Thirty patients were randomly allocated to three groups (n=10),who were anesthetized with intravenous injection of rocuronium (0.6mg/kg), atracurium (0.5mg/kg) or succinylcholine (1.5mg/kg). result Rocuronium had similar effects on intubation with atracurium but the effect was not as good as succinylcholine; In this case, onset time, recovery time and neuromuscular blockade duration were 86.25±27.13s, 29.90±6.25min and 20.84±7.95min, respectively. Conclusion Rocuronium has good effect on intubation and has less side effects than succinylcholine.