HPV检测在宫颈病变中的诊断价值

HPV detection in the diagnosis of cervical lesions

目的探讨人乳头瘤病毒(HPV)与宫颈糜烂、宫颈CIN及宫颈癌之间的关系,HPV感染与ASCUS病变的关系。方法对169例宫颈细胞学诊断为ASCUS以上的患者行高危型人乳头瘤病毒(HPV-DNA)检测及阴道镜下多点活检。结果 169例ASCUS以上患者中,阳性114例,阴性55例,阳性人数占67.46%。其中炎症阳性27例,CINⅠ级阳性57例,CINⅡ级阳性11例,CINⅢ阳性11例,宫颈癌阳性8例。结论在细胞学检查为ASCUS以上的患者中,HPV病毒载量值两组间无明显差异,随着宫颈病变级别的升高,感染率呈升高趋势。

Objective To investigate the human papillomavirus（HPV） and cervical erosion,cervical CIN and cervical cancer between,HPV infection in the relationship between ASCUS lesions.Methods 169 cases of cervical cytology diagnosis of ASCUS or more high-risk patients with HPV-DNA testing milk-based and multi-point biopsy under colposcopy.Results Of more than 169 cases of ASCUS patients,114 cases of positive and negative in 55 cases,the positive figure represents 67.46%,of which 21 were positive for inflammation,57 cases were CINⅠ-level positive,11 were CINⅡ-level positive,11 were CINⅢ-level positive and 8 were cervical cancer positive.Conclusion Cytology in patients with ASCUS or more,HPA viral load is no significant difference between the two lesions,with elevated levels of cervical lesions,the infection rate shows an increasing trend.