氨氯地平长期治疗稳定型心绞痛的临床疗效

Long-term follow-up of amlodipine in the treatment of patients with stable angina pectoris

目的:观察氨氯地平长期治疗冠心病心绞痛的临床疗效和安全性.方法:在治疗前后应用运动平板试验来评价心绞痛患者的临床疗效,并观察氨氯地平治疗的不良反应.结果:氨氯地平缓解心绞痛的临床症状总有效率在治疗1.5、6、18mo后分别为86.7%、93.3%、93.3%.氨氯地平对HR无明显的影响,并可使BP降低.运动试验的结果表明氨氯地平可以明显的延长总的运动时间和运动到ST降低1mm的时间,显著地提高最大运动负荷量(Mets).随着时间的推移运动耐量进一步提高.结论:氨氯地平是一种长效、不良反应少的抗心绞痛和降BP的药物,适用于冠心病合并高血压患者.

AIM:To observe clinical efficacy and safety of amlodipine in the treatment of patients with stable angina pectoris for a long-term follow-up. METHODS :Following a one-week wash-out period, 30 patients were admitted for treatment with amlodipine 5 mg once daily. Double dosage was required if there was no evidence of improvement of myocardial ischemia in wk 3. RESULTS:The clinical total effective rate of amlodipine was 93. 3% after 18 mo. There was no electrocardiographic improvement. No influence to heart rate in amlodipine treatment. Amlodipine reduced blood pressure(systolic and diastolic)as nifedipine ,and kept a maximal clinical effect last to 8 wk. Treadmill exercise results showed the amlodipine prolonged the total exercise time and time to ≥1mm ST depression,and increased the maximal exercise loads(Mets)after 6 wk of treatment. CONCLUSION:The amlodipine is an effective and safe drug for long-term treatment of stable angina pectoris,especially patients of coronary heart disease with hypertention.