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肺炎克雷伯菌产超广谱β-内酰胺酶研究进展 被引量：2

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摘要 产超广谱β-内酞胺酶（ESBLs）是肺炎克雷伯菌产生耐药的主要机制。ESBLs大多源于TEM、SHV位的基因突变,由1~4个氨基酸替换而形成新的酶蛋白,它的基因型主要包括TEM、SHV、CTX-M、OXA及其他少见类型,其中以TEM、SHV、CTX-M最常见,并呈全球分布[1]。下面分述ES-BLs的生物学特点。
作者 舒艳 况九龙
机构地区 南昌大学第二附属医院
出处 《山东医药》 CAS 北大核心 2011年第21期110-112,共3页 Shandong Medical Journal
基金 江西省卫生厅科技计划项目(0301069)
关键词 肺炎克雷伯菌 超广谱Β-内酰胺酶 耐药性
分类号 R378.996 [医药卫生—病原生物学]
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参考文献10

  • 1Tofteland S,Haldorsen B,Dahl KH,et al.Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of escherichia coli and klebsiella pneumoniae in Norway[J].J Clin Microbiol,2007,45(1):199-205.
  • 2Lytsy B,Sandegren L,Tano E,et al.The first major extended-spectrum beta-lactamase outbreak in scandinavia was caused by clonal spread of a multiresistant klebsiella pneumoniae producing CTX-M-15[J].APMIS,2008,116(4):302-308.
  • 3Livermore DM,Canton R,Gniadkowski M,et al.CTX-M:changing the face of ESBLs in Europe[J].J Antimicrob Chemother,2007,59(2):165-170.
  • 4Empel J,Baraniak A,Literacka E,et al.Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in enterobacteriaceae isolates from polish hospitals[J].Antimicrob Agents Chemother,2008,52(7):2449-2454.
  • 5Damjanova I,Tóth A,Pászti J,et al.Expansion and countrywide dissemination of ST11,ST15 and ST147 ciprofoxacin-resistant CTX-M-15-type {beta}-lactamase-producing klebsiella pneumoniae epidemic clones in Hungary in 2005--the new ‘MRSAs'[J].J Antimicrob Chemother,2008,62(5):978-985.
  • 6Korten V,Ulusoy S,Zarakolu P,et al.Antibiotic resistance surveillance over a 4-year period (2000-2003) in Turkey:results of the MYSTIC program[J].Diagn Microbiol Infect Dis,2007,59(4):453-457.
  • 7Castanheira M,Mendes RE,Rhomberg PR,et al.Rapid emergence of blaCTX-M among enterobacteriaceae in US medical centers:molecular evaluation from the MYSTIC program (2007)[J].Microb Drug Resist,2008,14(3):211-216.
  • 8Ensor VM,Shahid M,Evans JT,et al.Occurrence,prevalence and genetic environment of CTX-M b-lactamases in enterobacteriaceae from Indian hospitals[J].J Antimicrob Chemother,2006,58(6):1260-1263.
  • 9Hanson ND,Moland SE,Pitout JD.Enzymatic characterization of TEM-63,a TEM-type extended spectrum beta-lactamase expressed in three different genera of enterobacteriaceae from South Africa diagn[J].Microbiol Infect Dis,2001,40(4):199-201.
  • 10Kariuki S,Corkill JE,Revathi GR,et al.Molecular characterization of a novel plasmid-encoded cefotaximase (CTX-M-12) found in clinical klebsiella pneumoniae isolates from Kenya antimicrob[J].Agents Chemother,2001,45(7):2141-2143.

同被引文献15

  • 1张阮章,王沙燕,卢月梅,何林,陈升汶.产超广谱β-内酰胺酶大肠埃希菌和肺炎克雷伯菌blaCTX-M基因的检测[J].中国微生态学杂志,2004,16(6):342-344. 被引量：12
  • 2刘朝晖,张盛斌,王汉平,杨银梅.运用变性高效液相色谱快速检测CTX-M超广谱β内酰胺酶基因型[J].中国感染与化疗杂志,2006,6(6):384-388. 被引量：3
  • 3陈天宝,陈建魁,尹秀云.超广谱β内酰胺酶检测方法研究进展[J].中国卫生检验杂志,2007,17(6):1144-1147. 被引量：5
  • 4Bauernfeind A,Grimm H,Schweighart S.A new plasmi-dic cefotaximase in a clinical isolate of Escherichia coli[J].Infection,1990,18(3):294-298.
  • 5Abdalhamid B,Pitout JD,Moland ES,et al.Community-onset disease caused by Citrobacter freundii producing a novel CTX-M beta-lactamase,CTX-M-30,in Canada[J].Antimicrob Agents Chemother,2004,48(11):4435-4437.
  • 6Cartelle M,del Mar Tomas M,Molina F,et al.High-level resistance to ceftazidime conferred by a novel enzyme,CTX-M-32,derived from CTX-M-1 through a single Asp240-Gly substitution[J].Antimicrob Agents Chemother,2004,48(6):2308-2313.
  • 7Bonnet R,Sampaio JL,Labia R,et al.A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil[J].Antimicrob Agents Chemother,2000,44(7):1936-1942.
  • 8Poirel L,Naas T,Le Thomas I,et al.CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop[J].Antimicrob Agents Chemother,2001,45(12):3355-3361.
  • 9Boyd DA,Tyler S,Christianson S,et al.Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto,Canada[J].Antimicrob Agents Chemother,2004,48(10):3758-3764.
  • 10Barlaan EA,Sugimori M,Furukawa S,et al.Profiling and monitoring of microbial populations by denaturing high-performance liquid chromatography[J].J Microbiol Methods,2005,61(3):399-412.

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二级引证文献9

山东医药
2011年 第21期

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