医用钛合金微弧氧化膜的制备及其生物相容性研究

Preparation and biocompatibility study of medical micro-arc oxidation coating on titanium alloy

利用微弧氧化技术在Ti合金表面制备了医用羟基磷灰石(HA)膜,研究了HA膜在模拟体液中的生物相容性,通过SEM观察了HA膜在模拟体液中浸泡不同时间的表面形貌,并利用EDS测试了HA膜浸泡前后的Ca、P原子分数。结果表明,HA膜在模拟体液中浸泡后,体液的pH变化不大,而经过溶解–重结晶,新生成的HA晶粒发育更完整,更利于膜层与骨的结合;HA膜的钙磷比在浸泡前为1.97,浸泡20d后下降为1.66,接近于人体骨骼标准。

A medicinal hydroxyapatite（HA） coating was fabricated on the surface of titanium alloy with micro-arc oxidation process,and the biocompatibility of the HA coating in simulated body fluid（SBF） was studied. The surface morphology of the HA coating immersed in SBF for different time was observed by SEM,and the atomic fractions of Ca and P in HA coating before and after immersion were determined by EDS. Results proved that the pH of SBF is slightly changed after immersion of HA coating in it,and the regenerated HA grains grow more completely during dissolution–recrystallization,resulting in favorable combination of the coating with bones. Ca/P ratio of the HA coating was decreased from 1.97 before immersion to 1.66 after immersion for 20 d,close to human body bones standard.