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HGF在治疗缺血性疾病中的应用

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摘要 肝细胞生长因子(hepatocyte growth factor,HGF)最初作为肝细胞有丝分裂原被提纯和克隆[1],它在各种细胞中有促有丝分裂、运动形成、形态发生及抗凋亡等作用[2]。HGF的多种作用是通过由细胞膜上c--met前癌基因编码的酪氨酸激酶受体介导附习。在生理上,HGF作为亲器官因子发挥作用,它对器官(包括肝、肾、心脏、肺)有保护和修复作用。更重要的是HGF有促进血管新生的作用,HGF可以血管内皮细胞生成而不会引起血管平滑肌细胞的增生。
作者 陈磊 杨植
出处 《承德医学院学报》 2011年第2期200-203,共4页 Journal of Chengde Medical University
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参考文献26

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