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基质金属蛋白酶-2与脑缺血损伤及修复 被引量:1

Matrix Metalloproteinase-2 Associated with Cerebral Ischemic Injury and Recovery(review)
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摘要 基质金属蛋白-2(MMP-2)是MMP家族中的一员,可降解细胞外基质。在脑缺血早期,MMP-2可通过破坏内皮细胞紧密连接和基底膜,使血脑屏障开放;脑缺血后期,MMP-2则能促进神经血管再生,有利于损伤脑组织的修复。 Matrix metalloproteinase-2(MMP-2),which is a member of MMP family,can degrade extracellular matrix.During the early stage of cerebral ischemia,MMP-2 degrades endothelial tight junction and basal lamina resulting in the opening of blood-brain barrier.During the late stage,MMP-2 promotes neurovascular regeneration and the recovery of the damaged brain tissue.
作者 马跃文 强琳
出处 《中国康复理论与实践》 CSCD 2011年第5期440-442,共3页 Chinese Journal of Rehabilitation Theory and Practice
基金 辽宁省教育厅高等教育科研项目计划(L2010646) 辽宁省科学技术计划项目(2010225034)
关键词 基质金属蛋白-2 脑缺血 综述 matrix metalloproteinase-2 cerebral ischemia review
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