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肝药酶CYP2C19基因多态性与氯吡格雷及质子泵抑制剂药物相互作用的研究进展 被引量：2

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摘要 氯吡格雷是目前临床用于抗血小板聚集最重要的药物之一,质子泵抑制剂（PPI）亦是近年来治疗酸相关性疾病最有效的药物。CYP2C19基因多态性与PPI、氯吡格雷的药效学、药代动力学密切相关,对临床治疗有重要的现实意义。
作者 余莲英 沙卫红 王启仪
机构地区 广东省人民医院消化内科
出处 《中国医学工程》 2011年第4期154-155,共2页 China Medical Engineering
基金 2010广东省科技计划项目(2010B031600152)
关键词 CYP2C19 药物相互作用 质子泵抑制剂 基因多态性 氯吡格雷 肝药酶 抗血小板聚集 酸相关性疾病
分类号 R914.2 [医药卫生—药物化学]
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参考文献10

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二级参考文献7

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共引文献5

同被引文献33

  • 1姜英杰,李瑜元,聂玉强,王红,沙卫红.根除幽门螺杆菌疗效与细胞色素氧化酶P450 2C19基因多态性的关系[J].中华消化杂志,2005,25(8):458-461. 被引量：8
  • 2付琼瑶,李佩琼,王九辉,蔡望伟.海南黎族人群细胞色素P4502C19基因多态性的研究[J].中国热带医学,2005,5(9):1807-1808. 被引量：9
  • 3胡祥鹏,胡咏梅,许建明,梅俏,徐新华,徐叔云.细胞色素P450 2C19基因多态性对奥美拉唑胶囊抑酸效果的影响[J].中国临床药理学杂志,2006,22(1):31-34. 被引量：7
  • 4刘厚钰,石虹.老年消化性溃疡的治疗[J].老年医学与保健,2007,13(1):5-7. 被引量：16
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引证文献2

二级引证文献13

中国医学工程
2011年 第4期

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