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Runx2基因与骨肉瘤研究进展 被引量：3

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摘要 RUNX蛋白是一类转录因子蛋白的统称，他们的分子结构中均含有一氨基酸组成相同的DNA结合区，该结合区由128个氨基酸组成并与果蝇属的分节基因Runt同源，由此而被称为Runt结构域。
作者 张洁林 闵大六 姚阳
机构地区 上海交通大学附属上海市第六人民医院肿瘤内科
出处 《癌症进展》 2011年第3期274-278,共5页 Oncology Progress
关键词 RUNX2 骨肉瘤 肿瘤形成
分类号 R738.1 [医药卫生—肿瘤]
  • 相关文献

参考文献38

  • 1Ito Y.Oncogenic potential of the RUNX gene family:Overview[J].Oncogene,2004,23 (24):4198.
  • 2Perry C,Eldor A,Soreq H.Runx1/AML1 in leukemia:Disrupted association with diverse protein partners[J].Leuk.Res,2002,26:221.
  • 3Yoshida T,Kanegane H,Miyawaki T,et al.Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations[J].Am J Hum Genet,2002,71:724.
  • 4Sudhakar S,Katz MS,Elangol N,et al.Analysis of type-Iand type-Ⅱ RUNX2 protein expression in osteoblasts:Biochemical and biophysical research communications[J].2001,286:74.
  • 5Pratap J,Galindo M,Zaidi SK,et al.Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts[J].Cancer Res,2003,63:5357.
  • 6Clark JC,Dass CR,Choong PF.A review of clinical and molecular prog2 nostic factors in osteosarcoma[J].J Cancer Res Clin Oncol,2008,134 (3):281.
  • 7Galindo M,Pratap J,Young DW,et al.The bonespecific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts[J].J Biol Chem,2005,280 (21):20274.
  • 8Choi JY,Pratap J,Javad A,et al.Subnuclear targeting of Runx/Cbfa tactorsisessential for tissue-specific differentiation during embryonic development[J].Proc Nat Acad Sci USA,2001,98 (15):8650.
  • 9Drissi H,Luc Q,Shakoor IR,et al.Transcriptional autoregulation of the bone related CBFα1/RUNX2 gene[J].J Cell Physiol,2000,184 (3):341.
  • 10Stock M,Otto F.Control of RUNX2 isoform expression:The role of promoters and enhancers[J].J Cell Biochem,2005,95 (3):506.

二级参考文献6

  • 1Clark JC,Dass CR,Choong PF..A review of clinical and molecular prognostic factors in osteosarcoma[J] .J Cancer Res Clin Oncol,2007, [Epub ahead of print].
  • 2Galindo M, Pratap J, Young DW, et al. The bone-specific expression of Runx2 oscillates during the cell cycle to support a Gl-related anfiproliferative function in osteoblasts[J]. J Biol Chera,2005,280(21 ):20274.
  • 3Nishimura M, Yuasa K, Moil K, et al. Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact [J] .J Orthop Res, 2005,23(5) :979.
  • 4Morrissey C, Kostenuik PL, Brown LG, et al. Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastasesBMC [ J]. Cancer, 2007,7:148.
  • 5Barger AM, Fan TM, de Lorimier LP, et al. Expression of receptor activator of nuclear factor kappa-B ligand (RANKL) in neoplasms of dogs and cats[J] .J Vet Intern Med,2007,21 (1) : 133.
  • 6Lamoureux F, Richard P, Wittrant Y, et al. Therapeutic relevance of osteoprotegerin gene therapy in ostcesarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption[J]. Cancer Res,2007, 67(15) :7308.

共引文献2

同被引文献48

  • 1赵亚恒,冯和林,郑丽华,贾志峰,冯建刚.骨肉瘤发病机制的研究进展[J].肿瘤防治研究,2014,41(3):283-286. 被引量：25
  • 2李丹,范哲,李广生.Runx2与骨生长发育[J].中国地方病学杂志,2004,23(6):620-623. 被引量：9
  • 3段学静,杨丕山,李纾,潘克清,谢瑞阅,马伯龙.Runx2/cbfa1在人牙胚发育过程中的表达[J].临床口腔医学杂志,2005,21(10):588-590. 被引量：3
  • 4lto Y. Oncogenic potential of the RUNX gene family: 'overview' [ J]. Oncogene ,2004,23 (24) :4198 - 4208.
  • 5Yoshida T, Kanegane H, Osato M, et al. Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations [ J ]. Am J Hum Genet,2002,71 (4) :724 - 738.
  • 6Camilleri S, McDonald F. Runx2 and dental development[ J]. Eur J Oral Sci,2006,114(5) :361 - 373.
  • 7Mundlos S, Otto F, Mundlos C,et al. Mutations involving the tran- scription factor CBFA1 cause cleidocranial dysplasia [ J ]. Cell, 1997,89(5):773-779.
  • 8Albrecht AN, Kornak U, Boddrich A,et al. A molecular pathogene- sis for transcription factor associated poly-alanine tract expansions [J]. Hum Mol Genet,2004,13(20) :2351 -2359.
  • 9Zhang YW, Yasui N, Ito K, et al. A RUNX2/PEBP2alpha A/CB- FA1 mutation displaying impaired transactivation and Smad inter- action in cleidocranial dysplasia[ J]. Proc Natl Acad Sei U S A, 2000,97 (19) : 10549 - 10554.
  • 10Sierra J, Villagra A, Paredes R, et al. Regulation of the bone-specif- ic osteocalcin gene by p300 requires Runx2/Cbfal and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity [J]. Mol Cell Biol,2003,23(9) :3339 -3351.

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癌症进展
2011年 第3期

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