监测尿N-乙酰β-D氨基葡萄糖苷酶对诊断妊高征早期肾损害的临床意义

Determine Minor Renal Damage in EPH Syndrome by the NAG in Urine.

目的 研究妊高征患者尿中N- 乙酰β- D 氨基葡萄糖苷酶( NAG) 变化规律,诊断早期肾损害。方法 选择妊高征患者80 例,正常妊娠40 例,其中妊高征患者分为轻、中、重三组,分别对其尿中NAG 活性进行测定及比较。结果 除轻度组与中度组比较无显著差异P > 0-05 外,其它各组间比较均有显著性差异P < 0-05 或P< 0-01 。结论 妊高征患者存在有不同程度早期肾损害,其尿中NAG 活性与妊高征程度有关,表明妊高征不仅降低了肾小球滤过率,同时可能影响了肾小管的功能。

Objective\ To diagnose minor renal damage in early stage by measuring the urine N-acetyl-β-D-glucosaminidast(NAG)changing in edema proteinuria hypertension(EPH)syndrome.Methods\ To test the activity of urine NAG from 80 cases of EPH syndrome and 40 normal pregnancies.The 80 patients were divided into 3 groups according to light,medium and serious degree.Results\ Only light and medium groups of EPH syndrome show unobviously different activity of NAG,(P>0 05)all other groups have obvious difference(P<0 05 or P<0 01).Conclusion\ Different degrees of minor rental harm happened in EPH syndrome patient.The activity of urine NAG is related to the extent of the syndrome.It proves that EPH syndrome not only decreases the filterability of glomerulus but also influences the function of uriniparous tubules.