早产妇女血清一氧化氮水平测定及研究

Study of Serum Nitric Oxide in Premature Labor

目的 探讨一氧化氮(NO) 水平与妊娠及早产的关系。方法 采用Greiss 法分别测定36 例早产妇女( 早产组) ,66 例妊娠妇女( 妊娠组) ,25 例非妊娠妇女( 非妊娠组) 静脉血中NO 的含量。结果 早产妇女血清NO浓度显著低于同孕龄及足月妊娠妇女( P < 0-01) ,低于足月妊娠临产妇女,但无显著差异( P > 0-05) 。足月妊娠临产妇女血清NO 浓度显著低于妊娠期妇女( P < 0-01) 。非妊娠组血清NO 浓度显著低于早产组及妊娠组( P <0-01) 。结论 妊娠期NO 浓度增加,NO 对维持正常妊娠和抑制子宫平滑肌收缩方面起到重要作用,NO 水平降低可能是导致早产发生的重要环节。

Objective\ To study the relationship between serum nitric oxide(NO)level and premature labor.Methods\ Serum NO was determined by Greiss reaction in 36 cases of premature delivery,66 cases of normal pregnancy and 25 cases of nonpregnant women.Results\ Serum NO in premature delivery group was significantly lower than that of the other two groups(P<0 01).Serum NO in term pregnant women who were in labor was significantly lower than that of those women who were not in labor (P<0 01)In nonpregnancy group,the serum NO was significantly lower than that of premature delivery group and term pregnancy group(P<0 01).Conclusions\ Serum NO increases during pregnancy.NO plays an important role in maintaining normal pregnancy and inhabiting contraction of uterine muscle.Decreasing of NO may be one of the crucial reason in premature delivery.