噻庚啶对多脏器功能失常综合征大鼠的影响

Influence of cyproheptadine on rats with multiple organ dysfunction syndrome

目的了解噻庚啶对多脏器功能失常综合征（ＭＯＤＳ）大鼠的防治作用，并揭示给药时间与防治效果之间的关系。方法用ＳＤ大鼠制作ＭＯＤＳ模型，观察噻庚啶及给药时间对血清相关生化指标的影响。结果噻庚啶保护组和非保护组比较，血清中超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显升高（Ｐ＜０．０５），丙二醛（ＭＤＡ）含量显著降低（Ｐ＜０．０５）；同时血清丙氨酸氨基转移酶（ＡＬＴ）、肌酸激酶（ＣＫ）和肌酐（Ｃｒ）均有相应的降低，且早期给药保护组与对照组比较差异有显著性意义（Ｐ＜０．０５），而晚期给药保护组与对照组比较差异无显著性意义（Ｐ＞０．０５）。结论噻庚啶能清除氧自由基，减轻细胞损伤和多器官功能衰竭；早期给药对保护重要脏器的功能有利。

Objective To investigate the protective effect of cyproheptadine (CPH) on rats with multiple organ dysfunction syndrome (MODS),and explore the relationship between the treatment time and the effects.Methods A rat model of MODS was produced.Serum biochemistry levels were measured.Results After treatment,it was shown that serum superoxide dismutase(SOD)、glutathione peroxidase(GSH-Px) activities were higher(P<0.05) and malondialdehype(MDA) contents were lower(P<0.05);serum alanime transaminse(ALT)、creatine kinase(CK) and creatinine(Cr) levels were lower as well.There were marked differences between early treatment group and non treatment group(P<0.05),but no significant difference in late treatment group(P>0.05).Conclusion The present study indicates that CPH can eliminate oxygen free radicals (OFR) and that early treatment can ease cell injury and MODS.