儿童咳嗽变异性哮喘与食物不耐受检测的相关性研究

Investigation on correlation between cough variant asthma and food intolerance in children

【目的】探索本地区咳嗽变异性哮喘(cough variant asthma,CVA)儿童食物不耐受情况,为咳嗽变异性哮喘儿童的病因诊断、预防和治疗提供新的实验室参考依据。【方法】随机选取门诊咳嗽变异性哮喘患儿65例,正常对照74例,检测其血清中14种食物特异性IgG抗体并对结果进行统计分析。【结果】患者组食物特异性IgG抗体阳性率为90.77%,明显高于对照组的21.62%,两组比较差异有高度统计学意义(P<0.001)。忌食不耐受食物后,患者症状明显好转。【结论】食物特异性IgG抗体测定有助于及早发现咳嗽变异性哮喘患者的病因,为诊治和预防提供依据。

【Objective】 To explore the correlation between cough variant asthma（CVA） and food intolerance in children,in order to provide evidence for diagnosis and treatment of the disease.【Methods】 65 patients with CVA（the study group） and 74 healthy cases（the control group） were investigated in this research.The food specific IgG was measured by ELISA.The serum concentrations of 14 kinds of food specific IgG were observed and compared between two groups.【Results】 The positive rate of food specific IgG in the study group was 90.77%,it was significantly higher than that of the control group 21.62%,and furthermore,the symptoms of the patients with CVA were obviously improved by avoiding taking the intolerance food.【Conclusions】 Determination of food specific IgG would be helpful to discover the cause of CVA earlier and to offer basis for diagnosis,treatment and prevention as well.