应用APACHEⅡ评分对急性有机磷农药中毒患者氯解磷定总用量估模的临床研究

Reseach on Application of Estimation Model about Total Amount of Pralidoxime Chloride with APACHEⅡon Treatment of Acute Organophosphorus Insecticide Poisoning Patients

目的:对有机磷农药急性中毒患者应用氯解磷定总用量估模值的救治方案进行治疗,观察其疗效。方法:对91例重度急性有机磷农药中毒(AOPP)患者就行救治,取中毒后第一个24小时内,病情最严重时的急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)的分值(X),代入(?)=-43.4+4.7X,计算出PAM.Cl总用量((?)),并按大量突击疗法应用至临床治愈,验证上述公式。结果:急性有机磷农药中毒患者的救治过程表明,氯解磷定实际总用量与总用量估模值一致。结论:通过APACHEⅡ评分系统初步估模出急性有机磷农药中毒患者氯解磷定总用量的值,是准确的。公式(?)=-43.4+4.7X是指导急性有机磷农药中毒时氯解磷定总量的有效方法,有利于指导用药。

Objective： The patents of acute organophosphorus insecticide poisoning were treated with the cure project of estimation value of the total dosage of pralidoxime chloride （PAM.Cl）. Methods： 91 cases of patents of acute organophnsphorus insecticide poisoning were treated. When their state of illness was the most serious, the scores （X） of the acute physiology and chronic health evaluation II （APACHE ll） were substituted in Y=-43.4＋4.7X in the first 24 hours, the total dosage （Y） of PAM.CI was calculated. The method of large quantity concentrated dose was used until clinical cure was achieved in order to prove the above formula. ResuRs： The process of cure of the patents of acute organophosphorus insecticide poisoning indicated that the actual total dosage of used pralidoxime chloride corresponded to the estimation value of the total dosage of used pralidoxime chloride. Conelusinon： The total dosage of pralidoxime chloride of highly toxic type organophosphorus insecticide poisoning patents that was initially estimated by the APACHE II score was accurate. The formula Y=43.4＋4.7X is an effective method that directs the total dosage of pralidoxime chloride of highly toxic type organophosphorus insecticide poisoning, it is of benefit to direct dosage.