丙种球蛋白辅助治疗小儿川崎病的疗效观察

Clinical Observation of Infantile Kawasaki Disease Treated by Gammaglobulin Adjunctive Therapy

目的:探讨不同剂量丙种球蛋白治疗小儿川崎病的临床疗效。方法:选取我院2006年7月～2009年8月收治的120例川崎病患儿的临床资料,随机分为A、B、C三组,每组40例,三组患者均采用静脉注射丙种球蛋白进行治疗,A组静脉滴注丙种球蛋白2g/kg;B组静脉滴注丙种球蛋白1g/kg×2d;C组静脉滴注丙种球蛋白0.4g/(kg·d)×5d,各组其他治疗相同。观测患儿退热、淋巴结肿大、粘膜充血消退、多形性皮疹及手足症状消退的时间及冠状动脉损害发生率(CAL),并进行统计学分析。结果:A组退热、淋巴结肿大、粘膜充血消退、多形性皮疹及手足症状消退时间较B、C组短,且差异有统计学意义(P<0.05)。B组与C组无明显差异(P>0.05),A、B、C各组CAL无显著性差异(P>0.05),三组均未见明显不良反应。结论:静脉丙种球蛋白2g/kg,单次给药治疗川崎病,能更好的退热,并有效预防冠状动脉并发症的发生,疗效满意值得在临床推广。

Objective： To investigate the dose immunoglobulin in clinical treatment of children with Kawasaki disease.Methods： The hospital in July 2006 - August 2009 120 patients admitted to the clinical data of children with Kawasaki disease were randomly divided into A, B, C three groups, each group 40 cases, three groups of patients were treated with intravenous globulin treatment, A group of intravenous gamma globulin 2g/kg; B group of intravenous gamma globulin lg/kg×2d; C group of intravenous gamma globulin 0.4g / （kg.d） × 5d,the same as other treatment groups. Observed in children with fever, swollen lymph nodes, mucosa congestion subsided and polymorphous skin rash and hand-foot time and remission rate of coronary artery lesions （CAL）, and analyzed statistically.Results： A group of fever, swollen lymph nodes, mucosa congestion subsided and polymorphous skin rash and remission time than hand-foot B, C was shorter, and the difference was statistically significant （P 〈0.05）. B group and C group no significant difference （P〉 0.05）, A, B, C CAL in each group no significant difference （P〉 0.05）, three groups were no obvious adverse reactions.Conclusion： Intravenous gamma globulin 2g/kg, single dose treatment of Kawasaki disease, better cooling, and prev.ent the occurrence of coronary complications, results were satisfactory in clinical promotion.