乌司他丁治疗中暑98例疗效观察

Clinical Observation on Treating 98 Cases of Sunstroke by Ulinastatin

目的:探讨乌司他丁治疗中暑患者的临床疗效。方法:选择2007年7月～2010年6月在本院急诊科就诊的中暑患者196例作为研究对象,将其按就诊先后顺序随机分为观察组和对照组各30例。对照组予以降温治疗(包括皮肤按摩,促进散热;冷水擦浴或蒸发散热降温;冰盐水直肠灌洗;氯丙嗪(25～50)mg加入生理盐水500ml中静脉滴注)、生命支持及对症处理等常规治疗。观察组在对照组常规治疗基础上予以乌司他丁(广东天普生化医药股份有限公司生产)10万U加入生理盐水100ml中静脉滴注,3次/d,连续应用1w,随访6w。结果:观察组体温恢复时间、血压恢复时间、意识恢复时间、平均住院日、存活率及血浆TNF-α、IL-6的含量测定方面均明显优于常规治疗组,两组比较差异经统计学处理有统计学意义(P<0.01或P<0.05)。结论:乌司他丁能通过抑制细胞因子的释放,保护重要脏器的功能并抑制机体的炎性反应,对中暑患者有较好的临床疗效。

Objective：To study the clinical curative effect of ulinastatin for sunstroke treatment.Methods： To select 196 sunstroke patients treated in the emergency clinic from July 2007 to June 2010 as the research objects, and then by the treatment orders, divide them into the observation group and the control group, each 30 cases. The control group is given the cooling treatment （including skin massage for promoting heat dissipation; cold water sponge bath or evaporation cooling; cold saline rectum lavage; chlorpromazine （25 to 50） mg adding to the the physiological saline in 500ml for intravenous injection）, and the life support and the remedy to the case and other conventional treatment. The observation group, based on the conventional treatment of control group, adds 100,000U of Ulinastatin （produced by Guangdong Tianpu Biochemical Medicine Co., LTD） to the 100ml physiological saline for intravenous injection, three times/d, and continuous application lw, follow-up 6w.Results：the measuring aspects of the observation group like temperature recovery time, blood pressure recovery time, consciousness recovery time, average day in hospital, survival and plasma TNF-α, IL-6 contents are obviously better than that of the conventional treatment group. The comparisons difference of two groups was statistically significant after statistics processing （P 〈 0.01 or P 〈 0.05）. Conclusion： Ulinastatin（UTI） can, through inhibiting the release of cytokines, protect the functions of the vital organs and suppress the inflammatory response ,which has good clinical curative effect for the sunstroke patients,.