早期干预对早产儿免疫功能的影响

The Influence of Early Intervention on the Immunity of Premature Infants

目的:探讨早期干预对早产儿免疫功能的影响。方法:胎龄(30～35)周早产儿77例被随机分为两组,早期干预组40例及对照组37例,早期干预方法为新生儿期的早期抚触及出院后的抚触加婴儿操,干预时间为2年。医护人员每3个月随访1次直到2年。检测两组患儿出生时、1月龄和24月龄时外周血T淋巴细胞亚群CD_3^+、CD_4^+、CD_8^+阳性率及血清免疫球蛋白IgG、IgA、IgM水平。结果:出生时及1月龄时两组早产儿外周血T淋巴细胞亚群CD_3^+、CD_4^+、CD_8^+阳性率及血清免疫球蛋白IgG、IgA、IgM水平无显著性差异(P>0.05),24月时早期干预组外周血T淋巴细胞亚群CD_3^+、CD_4^+、CD_8^+阳性率及血清免疫球蛋白IgG、IgA、IgM水平明显高于对照组(P<0.05)。结论:早期干预能够促进早产儿免疫功能的发育,提高早产儿的生活质量。

Objective： To determine the influence of early intervention on the immunity of premature infants.Methods：77 premature infants aged （30-35） weeks were randomly divided into testing group and comparing group. The methods of early intervention was touching and passive gynmastics. The period of early intervention was two years. The two groups were followed up every three months till they were 24 months old. The immunity of them was measured when they were born, one month old and 24 months old.Results：There was no remarkable difference（P〉0.05）between the two groups in their immunity when they were born and when they were one month old. However, there was remarkable difference （P〈0.05） between the two groups in immunity when they were 24 months old.Conclusion：Early intervention may accelerate the development of immunity of premature infants.