结核分枝杆菌耐药性分析

Investigation on the Drug Resistance Status of Mycobacterium Tuberculosis Strains

目的:回顾性分析结核分枝杆菌耐药状况。方法:分析分离培养出并使用噻吩-2羧基肼(TCH)和对硝基苯甲酸(PNB)进行分型确认的127株结核分枝杆菌药物敏感试验结果,包括异烟肼(H)、利福平(R)、链霉素(S)、乙胺丁醇(E)、吡嗪酰胺(Z)、力克肺疾(D)、氧氟沙星(O)、丙硫乙烟胺(TH)、卷曲霉素(C)、对氨基水杨酸钠(P)、丁胺卡那(AK)。11种药物采用绝对浓度法进行药物敏感性检测。结果:127株结核分枝杆菌中,R耐药率最高,高浓度药物耐药达74%、C耐药率最低,高浓度药物耐药率为3.9%;HR联合耐药率为67.7%,HRS联合耐药率为52%,CThZ联合耐药率为9.4%,同时对7种药物耐药的耐药率为39.4%,同时对11种药物的耐药率为11%。结论:结核分枝杆菌耐药情况已很严重,需要更严格的执行结核病预防和治疗。

Objective： To analyze retrospectively the status of drug resistance of mycobacterium tuberculosis.Methods：127 strains mycobacterium tuberculosis were identified by TCH and PNB. We analyzed the results of drug susceptibility testing by absolute concentration among 11 ugs, including H, R, S, E, Z, D, O, TH, C, P, AK.Results：Of 127 strains mycobacterium tuberculosis, high concentrations of H resistance rate is 74%, high concentrations of C resistance rate is 3.9%, 67.7% isolates were resistant to HR drugs, 52% were resistant to HRS drugs, 9.4% were resistant to CThZ drugs, 39.4% isolates were resistant to all seven drugs, 11% were resistant to all eleven drugs.Conclusion： The situation of drug resistance is very serious. More strict execution should be taken to prevent and treat tuberculosis.