321株铜绿假单胞菌分布及耐药性分析

Analysis of 321 Pseudomonas Aeruginosa Distribution and Their Drug Resistance

目的:了解医院感染铜绿假单胞菌(PAE)在临床的分布及耐药性,为临床医师合理用药提供依据。方法:回顾性调查我院2005年1月至2007年12月PAE的感染情况对分离的321株PAE药敏结果进行统计分析。结果:321株PAE主要分布在呼吸内科脑外科和消化内科的重症监护病房(ICU),PAE对13种抗菌药物药敏试验结果表明耐药率≥50.0%的抗菌药物有头孢噻肟90%、庆大霉素77.6%、头孢吡肟54.8%;头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、阿米卡星、环丙沙星等抗菌药物尚有较高的敏感率;亚胺培南和美罗培南的耐药率均为15.6%和1 6.2%。结论:PAE是医院感染的主要病原菌之一,临床医师在治疗时应根据药敏结果和抗菌药物的药理学特点合理选用抗菌药物,以提高疗效并减少耐药菌株产生。

Objective： To understand nosocomial infection of Pseudomonas aeruginosa （PAE） in the clinical distribution and drug resistance, for clinicians rational drug provide the basis.Methods： We retrospective survey in our hospital from January 2005 to December 2007 the infection of PAE on the separation of 321 PAE drug susceptibility results analyzed.Results：321 PAE mainly in the Respiratory Medicine Department of Gastroenterology, brain surgery and the intensive care unit （ICU）, PAE for 14 antimicrobial agents in the drug susceptibility test results showed that the rate of _〉 50.0% of antimicrobial drugs cefotaxime 90%, gantamicin ADM 77.6%, cefepime 54.8%; cefoperazone / sulbactam, piperacillin / tazobactam, amikacin, ciprofloxacin and other antibiotics are still sensitive to the higher rate; PEI imipenem and meropenem resistance rates were 15.6% and 16.2%.Conclusion： PAE is one of the main pathogens of nosocomial infection, clinicians in the treatment shall be based on antimicrobial susceptibility results and the pharmacological characteristics of a reasonable use of antimicrobial agents to enhance efficacy and reduce drug-resistant strains.