兔蛛网膜下腔出血后外周血中IL-2的变化及其意义探讨

Changes in IL-2 of the preipheral blood and its significance follwing subarachnoid hemorrhage in the rabbits

目的探讨免疫因素在蛛网膜下腔出血后迟发性脑血管痉挛的发生机制中的作用。方法采用兔复制动物模型，经颅多普勒监测血管痉挛发生情况，实验前后检测外周血IL－2活性。结果实验组动物迟发性脑血管痉挛的发生率达84．62％；实验第7天实验组外周血中IL－2活性较实验前显著增高（P＜0．01）。结论在蛛网膜下腔出血后迟发性脑血管痉挛的发生机制中确有免疫因素的参与。

Objective To investigatc the effect of immune factors on the mechanism ofpathogenesis in delayed cereblal vasospasm (DCVS) following suharechnoid hemorrhage(SAH).Method Rabbits were uscd to produce models of SAH and transcranial doppler ultrasound wasused to monitor the occurience of cerebrovasospasm. The IL - 2 in peripheral blood was examinedbefore and after the experiment. Results The incidence of DCVS was 84. 26%, and the level ofIL - 2 in peripheral blood was significantly higher on the 7th day afer experiment than that beforein the experimental group(P<0. 01 ). Concluson The immune factors might be involved inthe mechanism of pathogenesis DCVS following SAH.