不同中医方案治疗子宫内膜异位症的临床研究

Clinical study of different therapeutic protocols in treating endometriosis

目的比较3种不同中医方案治疗湿热瘀阻型子宫内膜异位症的临床疗效。方法将117例病例随机分为中药口服(红藤方)组31例、中药灌肠(内异灌肠方)组27例、中药灌肠加口服组29例、西药组(达那唑)30例。疗程均为3个月。观察临床疗效、症状评分、内膜异位灶等变化情况。结果各组临床疗效差异无统计学意义(P>0.05)。3个中医治疗组治疗后及停药3个月后痛经评分均显著降低(P<0.05);中药口服组、中药口服加灌肠组治疗后内膜异位灶均缩小(P<0.05);中药灌肠组与中药口服组、中药口服加灌肠组治疗后评分差异有统计学意义(P<0.05)。结论内异灌肠方、红藤方能不同程度地改善子宫内膜异位症患者的临床症状,缩小病灶;中药口服、中药口服结合灌肠治疗在改善痛经症状方面优于单纯中药灌肠。

Objective To compare the clinical efficacy of three different therapeutic protocols on endometriosis.Methods A multi-center randomized controlled study was made.One hundred and seventeen cases of endometriosis were randomly divided into ＂Hongteng Decoction＂ group,＂Enema Decoction＂ group,＂Hongteng Decoction＂ plus ＂Enema Decoction＂ group,and danazol group.Clinical effect,scores of symptoms and ectopic endometrium were observed.ResultsThere was no difference in the clinical efficacy between the four groups（P〉0.05）.The scores of dysmenorrhea right after treatment and after three-month drug withdrawal in the three Chinese medicine group were lower than those before treatment（P〈0.05）.Ectopic endometrium in the ＂Hongteng Decotion＂group and the ＂Hongteng Decoction＂plus ＂Enema Decoction＂group were all reduced（P〈0.05）.Conclusions ＂Enema Decoction＂ and ＂Hongteng Decoction＂ may improve clinical symptoms of endometriosis,reduce ectopic endometrium;oral ＂Hongteng Decoction＂ with possible ＂Enema Decoction＂ is superior to single ＂Enema Decoction＂.