抗Sm抗体阳性系统性红斑狼疮临床特征探讨

Analysis of clinical features of systemic lupus erythematosus with positive anti Sm antibody

为了探讨抗Ｓｍ 抗体阳性的系统性红斑狼疮（ＳＬＥ） 的临床特征， 对４９ 例抗Ｓｍ 抗体阳性ＳＬＥ 患者的临床资料进行了分析，并与８５ 例抗Ｓｍ 抗体阴性ＳＬＥ 患者的临床资料进行比较。结果显示抗Ｓｍ 抗体阳性ＳＬＥ 患者的病程较短， 光敏感、关节痛和雷诺氏现象较多见（ Ｐ＜ ０．０１ 或Ｐ＜ ０．０５） ，白细胞减少、蛋白尿、补体Ｃ３ 下降的发生率较高（ Ｐ＜ ０．０１ 或Ｐ＜０．０５） 。说明抗Ｓｍ 抗体阳性ＳＬＥ患者的临床表现明显， 易被作出早期诊断。

In order to describe clinical features of systemic lupus erythematosus(SLE) with positive anti Sm antibody, the clinical data of 49 cases of SLE with positive anti Sm antibody were analyzed and compared with those of 85 cases of SLE with negative anti Sm antibody. The results showed that the course of disease in the former was shorter than that in the latter. Photo sensitivity, arthralgia and Raynaud's phenomenon were observed more frequently in SLE patients with positive anti Sm antibody (P less than 0 01 or 0 05), leucopenia, proteinuria and low levels of C3 had a higher incidence in them with positive anti Sm antibody (P less than 0 01 ot 0 05). It is suggested that the clinical manifestations are more obvious and the early diagnosis is easily determined in SLE patients with positive anti Sm antibody .