流浪与正常住院精神障碍患者常见抗原抗体检测结果对照研究

Comparative study of common antigen-antibody test results in Wandering mental disorders and psychotic inpatients

目的:了解流浪乞讨精神障碍患者常见抗原抗体阳性携带情况。方法:对2005年10月至2009年9月在南京市青龙山精神病院住院的流浪精神障碍患者701例采用金标记免疫分析技术(胶体金法)检测乙肝五项、抗HIV、抗Tp抗体;采用ELISA法检测抗HAV、抗HCV抗体,同期正常住院的460例精神病患者为对照组,并对检测结果进行统计学分析。结果:701例流浪精神障碍患者抗Tp抗体阳性率4.1%(其中男性2.2%,女性6.2%,女性显著高于男性,P<0.01),HBV总感染率45.4%,抗-HBs阳性率31.8%,显著高于对照组(P<0.01);HBsAg阳性率9.3%,抗-HBc阳性率19.0%,高于对照组(P<0.05);抗-HCV阳性率2.4%,HBeAg阳性率1.9%,抗-HBe阳性率5.8%,两组间差异无显著性(P>0.05);流浪精神障碍患者发现1例抗-HAV阳性和1例抗-HIV阳性。结论:流浪乞讨精神障碍患者是某些传染病感染的高危人群,女性流浪精神障碍患者是梅毒感染的高危人群,应该常规血清标志物检查,加强监管,积极预防和治疗。

Objective：To explore the vagrants and beggars patients with mental disorders carry common antigen-antibody-positive cases.Methods：To detected five of each patients hepatitis B,anti-HIV,anti-Tp antibody used by gold immunochromatographic assay（Colloidal Gold） in 701 cases of Wandering mental disorders in Qinglongshan mental hospital in Nanjing from October 2005 to September 2009,by ELISA detection of anti HAV,anti-HCV antibodies,and 460 psychotic inpatients at the same period as control group were involved in the study,and the results were statistically analyzed.Results： 701 cases of Wandering mental disorders positive rate of anti-Tp antibody 4.1%（male 2.2%,female 6.2%,females were significantly higher than males P〈0.01）,HBV total infection rate was 45.4%,anti-HBs positive rate was 31.8%,significantly higher than the control group（P〈0.01）;HBsAg positive rate was 9.3%,anti-HBc positive rate was 19.0%,higher than the control group（P〈0.05）;anti-HCV positive rate was 2.4%,HBeAg-positive rate was 1.9% anti-HBe positive rate was 5.8%,the difference between the two groups was not significant（P〉0.05）;1 case of anti-HAV-positive and 1 anti-HIV positive were found in homeless people with mental disorders.Conclusions： vagrants and beggars with mental disorders have high risk of infectious diseases,Wandering women with mental disorders with have high risk of Treponema pallidum infection,serum markers should be routinely checked,strengthen supervision,active prevention and treatment.