有无幻听精神分裂症患者事件相关诱发电位P300测定分析

Study of the event-related potential P300 in schizophrenic patients with or without auditory hallucination

目的:探讨伴或不伴幻听对精神分裂症患者事件相关诱发电位P300的影响。方法:共收集18例伴有幻听和26例不伴幻听的首发精神分裂症患者,进行事件相关诱发电位P300测定,并用阳性与阴性症状量表(PANSS)判定其精神症状。结果:事件相关诱发电位P300测定显示伴有幻听精神分裂症患者P3波潜伏期延长,波幅降低,与不伴幻听的精神分裂症患者相比较差异均具有统计学意义(P<0.05)。相关分析显示P3波潜伏期与幻听呈显著正相关(r=0.29,P<0.05),波幅与幻听呈显著负相关(r=-0.18,P<0.05)。结论:伴或不伴幻听的精神分裂症可能有不同的神经生物学基础。

Objective：To investigate the effects of event-related potential P300 in schizophrenic patients with or without auditory hallucination.Methods：The event-related potential P300 were recorded from 18 schizophrenic patients with auditory hallucination and 26 schizophrenic patients without auditory hallucination.At the same time,their clinical symptoms were evaluated by positive and negative symptom scale（PANSS）.Results： The amplitude and the latency of waves P300 in schizophrenic patients with auditory hallucination were shorter and higher than that in schizophrenic patients without auditory hallucination,and there were significant difference in the two groups（P〈0.05）.There was a remarkable positive correlation between P300 latency and auditory hallucination（P〈0.05）,and a significantly negative correlation between P300 amplitude and auditory hallucination（P〈0.05）.Conclusions： The findings support that there are some biological differences in schizophrenic patients with or without auditory hallucination.